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ENZYME

ENZYME entry: EC 3.6.1.55

Accepted Name
8-oxo-dGTP diphosphatase
Alternative Name(s)
7,8-dihydro-8-oxo-dGTP pyrophosphohydrolase
7,8-dihydro-8-oxoguanine triphosphatase
8-oxo-dGTPase
Reaction catalysed
8-oxo-dGTP + H2O <=> 8-oxo-dGMP + diphosphate + H(+)
Comment(s)
  • This enzyme hydrolyzes the phosphoanhydride bond between the alpha and beta phosphate of 8-oxoguanine-containing nucleoside di- and triphosphates thereby preventing misincorporation of the oxidized purine nucleoside triphosphates into DNA.
  • It does not hydrolyze 2-hydroxy-dATP (cf. EC 3.6.1.56).
Cross-references
BRENDA3.6.1.55
EC2PDB3.6.1.55
ExplorEnz3.6.1.55
PRIAM enzyme-specific profiles3.6.1.55
KEGG Ligand Database for Enzyme Nomenclature3.6.1.55
IUBMB Enzyme Nomenclature3.6.1.55
IntEnz3.6.1.55
MEDLINEFind literature relating to 3.6.1.55
MetaCyc3.6.1.55
Rhea expert-curated reactions3.6.1.55
UniProtKB/Swiss-Prot
P9WIY0, MUTT2_MYCTOP9WIY1, MUTT2_MYCTUP9WIX8, MUTT3_MYCTO
P9WIX9, MUTT3_MYCTUP96590, MUTT_BACSUP57298, MUTT_BUCAI
Q8K9U2, MUTT_BUCAPP08337, MUTT_ECOLIP44932, MUTT_HAEIN
P32090, MUTT_PROVUP95781, MUTX_STRMUP41354, MUTX_STRPN
P59659, MUTX_STRR6Q9CA40, NUDT1_ARATHO35013, YTKD_BACSU

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.6.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.6.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-