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NiceZyme View of ENZYME: EC 3.5.4.16

Official Name
GTP cyclohydrolase I.
Reaction catalysed
GTP + H(2)O <=> formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate
Comment(s)
  • The reaction involves hydrolysis of two C-N bonds and isomerization of the pentose unit; the recyclization may be non-enzymic.
  • Involved in the de novo synthesis of tetrahydrobiopterin from GTP, with the other enzymes involved being EC 1.1.1.153 and EC 4.2.3.12.
Cross-references
Biochemical Pathways; map number(s)K1
PROSITEPDOC00672
BRENDA3.5.4.16
PUMA23.5.4.16
PRIAM enzyme-specific profiles3.5.4.16
KEGG Ligand Database for Enzyme Nomenclature3.5.4.16
IUBMB Enzyme Nomenclature3.5.4.16
IntEnz3.5.4.16
MEDLINEFind literature relating to 3.5.4.16
MetaCyc3.5.4.16
UniProtKB/Swiss-Prot
Q9CGE3, FOLKE_LACLA;  Q8GJP4, FOLKE_LACLM;  Q8YLL1, GCH11_ANASP;  
Q9HYG8, GCH11_PSEAE;  Q88LV4, GCH11_PSEPK;  Q887V1, GCH11_PSESM;  
Q8YN49, GCH12_ANASP;  Q9I351, GCH12_PSEAE;  Q88JY1, GCH12_PSEPK;  
Q884Q3, GCH12_PSESM;  A3N0R3, GCH1_ACTP2;  A0KIN6, GCH1_AERHH;  
A4SPE8, GCH1_AERS4;  Q8UEK8, GCH1_AGRT5;  Q0A939, GCH1_ALHEH;  
O66603, GCH1_AQUAE;  A8HUG2, GCH1_AZOC5;  A7Z630, GCH1_BACA2;  
A0RBW5, GCH1_BACAH;  Q81SW2, GCH1_BACAN;  Q73AY4, GCH1_BACC1;  
A7GN48, GCH1_BACCN;  Q81FQ8, GCH1_BACCR;  Q63DM1, GCH1_BACCZ;  
Q5L925, GCH1_BACFN;  Q64P85, GCH1_BACFR;  Q9KCC7, GCH1_BACHD;  
Q6HL44, GCH1_BACHK;  A8FEL2, GCH1_BACP2;  P48063, GCH1_BACPU;  
P19465, GCH1_BACSU;  Q8A0U0, GCH1_BACTN;  A1USJ5, GCH1_BARBK;  
Q6G3J8, GCH1_BARHE;  Q6FZZ4, GCH1_BARQU;  Q1LT77, GCH1_BAUCH;  
Q8G3S1, GCH1_BIFLO;  Q7VRX3, GCH1_BLOFL;  Q492J7, GCH1_BLOPB;  
Q89IW2, GCH1_BRAJA;  Q2YQ03, GCH1_BRUA2;  Q57D61, GCH1_BRUAB;  
A9M586, GCH1_BRUC2;  Q8YH94, GCH1_BRUME;  A5VQL0, GCH1_BRUO2;  
B0CGM4, GCH1_BRUSI;  Q8G0L4, GCH1_BRUSU;  Q8KA05, GCH1_BUCAP;  
Q19980, GCH1_CAEEL;  A7ZB36, GCH1_CAMC1;  A7GW42, GCH1_CAMC5;  
A8FJZ5, GCH1_CAMJ8;  A7H1R1, GCH1_CAMJD;  P51594, GCH1_CAMJE;  
A1VXS2, GCH1_CAMJJ;  Q5HWX4, GCH1_CAMJR;  Q3ADI2, GCH1_CARHZ;  
Q9AAY3, GCH1_CAUCR;  P50141, GCH1_CHICK;  Q3ATN0, GCH1_CHLCH;  
Q8KEA8, GCH1_CHLTE;  Q1QV64, GCH1_CHRSD;  Q7NYZ2, GCH1_CHRVO;  
A8AE79, GCH1_CITK8;  Q97D54, GCH1_CLOAB;  A7FU67, GCH1_CLOB1;  
A5I231, GCH1_CLOBH;  A7GDP1, GCH1_CLOBL;  Q18BW7, GCH1_CLOD6;  
A0Q2L7, GCH1_CLONN;  Q0TRM0, GCH1_CLOP1;  Q8XLM2, GCH1_CLOPE;  
Q0STY9, GCH1_CLOPS;  A3DHH6, GCH1_CLOTH;  Q8FMG3, GCH1_COREF;  
A4QH94, GCH1_CORGB;  Q8NM84, GCH1_CORGL;  A9KFF3, GCH1_COXBN;  
A9NDB3, GCH1_COXBR;  Q83DE3, GCH1_COXBU;  Q3Z782, GCH1_DEHE1;  
A5FQD3, GCH1_DEHSB;  Q3ZYB5, GCH1_DEHSC;  Q9RYB4, GCH1_DEIRA;  
A4J5D0, GCH1_DESRM;  Q94465, GCH1_DICDI;  P48596, GCH1_DROME;  
A7ZNX6, GCH1_ECO24;  P0A6T7, GCH1_ECO57;  A8A214, GCH1_ECOHS;  
A1AD13, GCH1_ECOK1;  Q0TFT7, GCH1_ECOL5;  P0A6T6, GCH1_ECOL6;  
B1IYB6, GCH1_ECOLC;  P0A6T5, GCH1_ECOLI;  Q1R9R9, GCH1_ECOUT;  
A4WCI8, GCH1_ENT38;  Q82Z12, GCH1_ENTFA;  Q6D3N3, GCH1_ERWCT;  
P51597, GCH1_EUGGR;  A5FHM7, GCH1_FLAJO;  Q8RH43, GCH1_FUSNN;  
Q5KXT7, GCH1_GEOKA;  Q7NK98, GCH1_GLOVI;  Q7VM90, GCH1_HAEDU;  
Q4QKH4, GCH1_HAEI8;  A5UC59, GCH1_HAEIE;  A5UEW4, GCH1_HAEIG;  
P43866, GCH1_HAEIN;  Q0I3F6, GCH1_HAES1;  B0UUA9, GCH1_HAES2;  
Q2SPJ2, GCH1_HAHCH;  Q17WX5, GCH1_HELAH;  Q7VFG4, GCH1_HELHP;  
Q1CSU6, GCH1_HELPH;  Q9ZKS2, GCH1_HELPJ;  P56462, GCH1_HELPY;  
P30793, GCH1_HUMAN;  Q0BXB5, GCH1_HYPNA;  A6TBN8, GCH1_KLEP7;  
Q88ST4, GCH1_LACPL;  Q38WN0, GCH1_LACSS;  Q6ACQ1, GCH1_LEIXX;  
Q04P36, GCH1_LEPBJ;  Q056J8, GCH1_LEPBL;  Q72LY8, GCH1_LEPIC;  
Q8EYG1, GCH1_LEPIN;  Q92A75, GCH1_LISIN;  Q71Y82, GCH1_LISMF;  
Q8Y5X1, GCH1_LISMO;  A0AK45, GCH1_LISW6;  Q65TR0, GCH1_MANSM;  
Q0AM02, GCH1_MARMM;  Q11JM4, GCH1_MESSB;  Q607T5, GCH1_METCA;  
Q05915, GCH1_MOUSE;  P51598, GCH1_MUCHA;  P64208, GCH1_MYCBO;  
A1KPU4, GCH1_MYCBP;  A4T5P2, GCH1_MYCGI;  O69531, GCH1_MYCLE;  
A5U8T4, GCH1_MYCTA;  P64207, GCH1_MYCTU;  A1TG42, GCH1_MYCVP;  
P51599, GCH1_NEUCR;  Q2Y6B3, GCH1_NITMU;  A6X0X0, GCH1_OCHA4;  
P51596, GCH1_ONCMY;  O61573, GCH1_OSTOS;  A6LFE8, GCH1_PARD8;  
P57865, GCH1_PASMU;  A5D2D8, GCH1_PELTS;  Q4FL89, GCH1_PELUB;  
Q7N6K7, GCH1_PHOLL;  Q6LQL4, GCH1_PHOPR;  P51600, GCH1_PHYBL;  
Q7MWI5, GCH1_PORGI;  A4SF37, GCH1_PROVI;  Q15YG1, GCH1_PSEA6;  
Q3IF89, GCH1_PSEHT;  Q8ZWW5, GCH1_PYRAE;  Q8XZK8, GCH1_RALSO;  
P22288, GCH1_RAT;  Q98LQ6, GCH1_RHILO;  Q92QB4, GCH1_RHIME;  
Q7UJJ7, GCH1_RHOBA;  Q2IY20, GCH1_RHOP2;  Q6N4E7, GCH1_RHOPA;  
Q212N0, GCH1_RHOPB;  Q134L7, GCH1_RHOPS;  A8GN89, GCH1_RICAH;  
A8GUB6, GCH1_RICB8;  Q1RID0, GCH1_RICBR;  Q92I93, GCH1_RICCN;  
Q4ULX3, GCH1_RICFE;  A8F1F2, GCH1_RICM5;  Q9ZDE8, GCH1_RICPR;  
B0BXB8, GCH1_RICRO;  A8GRW0, GCH1_RICRS;  Q68WZ4, GCH1_RICTY;  
A9MK63, GCH1_SALAR;  Q57ME6, GCH1_SALCH;  Q5PE52, GCH1_SALPA;  
A9N6K0, GCH1_SALPB;  P64210, GCH1_SALTI;  P64209, GCH1_SALTY;  
O13774, GCH1_SCHPO;  A8GC24, GCH1_SERP5;  A1S2C7, GCH1_SHEAM;  
A3CZJ1, GCH1_SHEB5;  A6WIA1, GCH1_SHEB8;  A9KXZ9, GCH1_SHEB9;  
Q12SG0, GCH1_SHEDO;  A3QIQ4, GCH1_SHELP;  Q8E9L6, GCH1_SHEON;  
A4Y2K7, GCH1_SHEPC;  A0L1S4, GCH1_SHESA;  Q0HE51, GCH1_SHESM;  
Q0HZU8, GCH1_SHESR;  A1REU0, GCH1_SHESW;  Q31YW1, GCH1_SHIBS;  
Q32EN8, GCH1_SHIDS;  Q0T2X1, GCH1_SHIF8;  P0A6T8, GCH1_SHIFL;  
Q3Z053, GCH1_SHISS;  A6U8C2, GCH1_SINMW;  Q2NUE3, GCH1_SODGM;  
Q3K0Y1, GCH1_STRA1;  Q8E549, GCH1_STRA3;  Q8DZI5, GCH1_STRA5;  
Q82EE8, GCH1_STRAW;  Q9X8I3, GCH1_STRCO;  A8AZD8, GCH1_STRGC;  
Q8DUG2, GCH1_STRMU;  P0C0C2, GCH1_STRP1;  Q04MF9, GCH1_STRP2;  
Q8K7K9, GCH1_STRP3;  Q5XCA9, GCH1_STRP6;  P0A3E9, GCH1_STRP8;  
A2REL9, GCH1_STRPG;  P51595, GCH1_STRPN;  P0C0C1, GCH1_STRPY;  
P59656, GCH1_STRR6;  A4W1S9, GCH1_STRS2;  A3CKF4, GCH1_STRSV;  
A4VVH1, GCH1_STRSY;  Q5LYM8, GCH1_STRT1;  Q5M391, GCH1_STRT2;  
Q4J8S2, GCH1_SULAC;  Q980E8, GCH1_SULSO;  Q971G9, GCH1_SULTO;  
Q54769, GCH1_SYNE7;  Q8DJB8, GCH1_SYNEL;  Q2JR69, GCH1_SYNJA;  
Q2JPT8, GCH1_SYNJB;  Q5N623, GCH1_SYNP6;  Q55759, GCH1_SYNY3;  
Q47KU5, GCH1_THEFY;  Q8R7N2, GCH1_THETN;  Q9KLX5, GCH1_VIBCH;  
Q5E4E4, GCH1_VIBF1;  A7N6L2, GCH1_VIBHB;  Q87GZ6, GCH1_VIBPA;  
Q8D6I7, GCH1_VIBVU;  Q7MDE5, GCH1_VIBVY;  Q8D2N7, GCH1_WIGBR;  
Q7M933, GCH1_WOLSU;  Q8PEP3, GCH1_XANAC;  Q3BM80, GCH1_XANC5;  
Q8P3B0, GCH1_XANCP;  Q9PC02, GCH1_XYLFA;  Q87D63, GCH1_XYLFT;  
P51601, GCH1_YEAST;  A1JU09, GCH1_YERE8;  A7FJL1, GCH1_YERP3;  
Q8ZG15, GCH1_YERPE;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.5.4.-
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