| Official Name |
|---|
| Anthrax lethal factor endopeptidase.
|
| Alternative Name(s) |
|---|
| Lethal toxin. |
| Reaction catalysed |
|---|
| Preferred amino acids around the cleavage site can be denoted BBBBxHx-|-H, in which B denotes Arg or Lys, H denotes a hydrophobic amino acid, and x is any amino acid. The only known protein substrates are mitogen-activated protein (MAP) kinase kinases |
| Cofactor(s) |
|---|
| Zinc.
|
| Comment(s) |
|---|
- From the bacterium Bacilus anthracis that causes anthrax.
- One of three proteins that are collectively termed anthrax toxin.
- Cleaves several MAP kinase kinases near their N-termini, preventing
them from phosphorylating the downstream mitogen-activated protein
kinases.
- Belongs to peptidase family M34.
|
| Cross-references |
|---|
| PROSITE | PDOC00129 |
| BRENDA | 3.4.24.83 |
| PUMA2 | 3.4.24.83 |
| PRIAM enzyme-specific profiles | 3.4.24.83 |
| KEGG Ligand Database for Enzyme Nomenclature | 3.4.24.83 |
| IUBMB Enzyme Nomenclature | 3.4.24.83 |
| IntEnz | 3.4.24.83 |
| MEDLINE | Find literature relating to 3.4.24.83 |
| MetaCyc | 3.4.24.83 |
| UniProtKB/Swiss-Prot |
|
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