| Accepted Name |
|---|
| Interstitial collagenase.
|
| Alternative Name(s) |
|---|
| Matrix metalloproteinase 1. |
| Vertebrate collagenase. |
| Reaction catalysed |
|---|
| Cleavage of the triple helix of collagen at about three-quarters of the length of the molecule from the N-terminus, at 775-Gly-|-Ile-776 in the alpha-1(I) chain. Cleaves synthetic substrates and alpha-macroglobulins at bonds where P1' is a hydrophobic residue |
| Cofactor(s) |
|---|
| Zinc.
|
| Comment(s) |
|---|
- The enzyme takes its name from substrates of the interstitial
collagen group - types I, II and III, all of which are cleaved in the
helical domain.
- Alpha-macroglobulins are cleaved much more rapidly.
- The enzyme is widely distributed in vertebrate animals.
- Belongs to peptidase family M10B.
|
| Cross-references |
|---|
| PROSITE | PDOC00129 |
| BRENDA | 3.4.24.7 |
| EC2PDB | 3.4.24.7 |
| PRIAM enzyme-specific profiles | 3.4.24.7 |
| KEGG Ligand Database for Enzyme Nomenclature | 3.4.24.7 |
| IUBMB Enzyme Nomenclature | 3.4.24.7 |
| IntEnz | 3.4.24.7 |
| MEDLINE | Find literature relating to 3.4.24.7 |
| MetaCyc | 3.4.24.7 |
| UniProtKB/Swiss-Prot |
| P34156, COG4_CHIOP; | Q9EPL5, MMP1A_MOUSE; | Q9EPL6, MMP1B_MOUSE; |
| P28053, MMP1_BOVIN; | Q9XSZ5, MMP1_HORSE; | P03956, MMP1_HUMAN; |
| P21692, MMP1_PIG; | P13943, MMP1_RABIT; | Q11133, MMP1_RANCA; |
| P81563, MMP1_RAT; |
|
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