| Official Name |
|---|
| Insulysin.
|
| Alternative Name(s) |
|---|
| Insulin protease. |
| Insulin-degrading enzyme. |
| Insulinase. |
| Reaction catalysed |
|---|
| Degradation of insulin, glucagon and other polypeptides. No action on proteins |
| Cofactor(s) |
|---|
| Zinc.
|
| Comment(s) |
|---|
- Cytosolic enzyme, known from mammals and Drosophila melanogaster.
- Inhibited by bacitracin, chelating agents EDTA and 1,10-
phenanthroline, and by thiol-blocking reagents such as
N-ethylmaleimide, but not by phosphoramidon.
- Belongs to peptidase family M16.
- Formerly EC 3.4.22.11, EC 3.4.99.10 and EC 3.4.99.45.
|
| Cross-references |
|---|
| PROSITE | PDOC00130 |
| BRENDA | 3.4.24.56 |
| PUMA2 | 3.4.24.56 |
| PRIAM enzyme-specific profiles | 3.4.24.56 |
| KEGG Ligand Database for Enzyme Nomenclature | 3.4.24.56 |
| IUBMB Enzyme Nomenclature | 3.4.24.56 |
| IntEnz | 3.4.24.56 |
| MEDLINE | Find literature relating to 3.4.24.56 |
| MetaCyc | 3.4.24.56 |
| UniProtKB/Swiss-Prot |
|
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