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NiceZyme View of ENZYME: EC 3.4.24.18

Official Name
Meprin A.
Alternative Name(s)
Endopeptidase-2.
Reaction catalysed
Hydrolysis of protein and peptide substrates preferentially on carboxyl side of hydrophobic residues
Cofactor(s)
Zinc.
Comment(s)
  • A membrane-bound metalloendopeptidase of rat and mouse kidney and intestinal brush borders, and salivary ducts.
  • Differences from EC 3.4.24.11 include insensitivity to phosphoramidon and thiorphan.
  • PABA-peptide hydrolase is a very similar enzyme found in human intestinal microvilli.
  • Belongs to peptidase family M12A.
Cross-references
PROSITEPDOC00129
BRENDA3.4.24.18
PUMA23.4.24.18
PRIAM enzyme-specific profiles3.4.24.18
KEGG Ligand Database for Enzyme Nomenclature3.4.24.18
IUBMB Enzyme Nomenclature3.4.24.18
IntEnz3.4.24.18
MEDLINEFind literature relating to 3.4.24.18
MetaCyc3.4.24.18
UniProtKB/Swiss-Prot
Q16819, MEP1A_HUMAN;  P28825, MEP1A_MOUSE;  Q64230, MEP1A_RAT;  
Q16820, MEP1B_HUMAN;  Q61847, MEP1B_MOUSE;  P28826, MEP1B_RAT;  

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