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NiceZyme View of ENZYME: EC 3.4.23.36

Accepted Name
Signal peptidase II.
Alternative Name(s)
Bacterial leader peptidase I.
Lipoprotein signal peptidase.
Premurein-leader peptidase.
Prolipoprotein-signal peptidase.
SPase II.
Reaction catalysed
Release of signal peptides from bacterial membrane prolipoproteins. Hydrolyzes -Xaa-Yaa-Zaa-|-(S,diacylglyceryl)Cys-, in which Xaa is hydrophobic (preferably Leu), and Yaa (Ala or Ser) and Zaa (Gly or Ala) have small, neutral side chains
Comment(s)
  • Inhibited by pepstatin and the antibiotic globomycin.
  • Belongs to peptidase family A8.
  • Formerly EC 3.4.99.35.
Cross-references
Biochemical Pathways; map number(s)M3 ; R4
PROSITEPDOC00669
BRENDA3.4.23.36
EC2PDB3.4.23.36
PRIAM enzyme-specific profiles3.4.23.36
KEGG Ligand Database for Enzyme Nomenclature3.4.23.36
IUBMB Enzyme Nomenclature3.4.23.36
IntEnz3.4.23.36
MEDLINEFind literature relating to 3.4.23.36
MetaCyc3.4.23.36
UniProtKB/Swiss-Prot
B0C3E3, LSPA_ACAM1;  Q6FG03, LSPA_ACIAD;  B7H305, LSPA_ACIB3;  
B0VMM0, LSPA_ACIBS;  A3M0S2, LSPA_ACIBT;  A6VQH9, LSPA_ACTSZ;  
A0KG40, LSPA_AERHH;  B4RVP1, LSPA_ALTMD;  B3EU56, LSPA_AMOA5;  
Q5P9U0, LSPA_ANAMM;  Q2GIV1, LSPA_ANAPZ;  Q8YNI8, LSPA_ANASP;  
Q3MA96, LSPA_ANAVT;  B7GFB0, LSPA_ANOFW;  O67692, LSPA_AQUAE;  
A1K4R6, LSPA_AZOSB;  A7Z4G5, LSPA_BACA2;  Q81WE6, LSPA_BACAN;  
B7JJY0, LSPA_BACC0;  Q732H6, LSPA_BACC1;  B7IUQ3, LSPA_BACC2;  
B7H6M9, LSPA_BACC4;  B7HLM7, LSPA_BACC7;  A7GRL8, LSPA_BACCN;  
Q636D3, LSPA_BACCZ;  Q9K9V2, LSPA_BACHD;  Q6HES1, LSPA_BACHK;  
A8FD10, LSPA_BACP2;  Q45479, LSPA_BACSU;  A9VTD3, LSPA_BACWK;  
A1UUG9, LSPA_BARBK;  Q6G5A2, LSPA_BARHE;  Q6G1A8, LSPA_BARQU;  
A9IL10, LSPA_BART1;  B2II67, LSPA_BEII9;  A1A2I0, LSPA_BIFAA;  
B3DQ87, LSPA_BIFLD;  Q8G7W3, LSPA_BIFLO;  Q7VQK9, LSPA_BLOFL;  
Q493S2, LSPA_BLOPB;  Q0SN37, LSPA_BORAP;  O51425, LSPA_BORBU;  
B7J235, LSPA_BORBZ;  B5RM28, LSPA_BORDL;  Q661F0, LSPA_BORGA;  
B2S0H3, LSPA_BORHD;  B5RRS4, LSPA_BORRA;  B2S8E3, LSPA_BRUA1;  
Q2YNY8, LSPA_BRUA2;  Q57FM7, LSPA_BRUAB;  A9M794, LSPA_BRUC2;  
Q8YES8, LSPA_BRUME;  A5VN85, LSPA_BRUO2;  B0CIQ7, LSPA_BRUSI;  
Q8G308, LSPA_BRUSU;  P57248, LSPA_BUCAI;  Q8K9Z3, LSPA_BUCAP;  
Q89AV0, LSPA_BUCBP;  B1YVA5, LSPA_BURA4;  Q1BUA0, LSPA_BURCA;  
B1JXC4, LSPA_BURCC;  A0K9T6, LSPA_BURCH;  B4E8Z8, LSPA_BURCJ;  
Q0BCK7, LSPA_BURCM;  A9AGN5, LSPA_BURM1;  A3MN08, LSPA_BURM7;  
A2S502, LSPA_BURM9;  Q62HL3, LSPA_BURMA;  A1V6V3, LSPA_BURMS;  
A3NSD0, LSPA_BURP0;  Q3JV70, LSPA_BURP1;  A3N6P6, LSPA_BURP6;  
B2JDY8, LSPA_BURP8;  B2T6I8, LSPA_BURPP;  Q63WI4, LSPA_BURPS;  
Q39DM7, LSPA_BURS3;  Q2T0H4, LSPA_BURTA;  A4JH33, LSPA_BURVG;  
A8FKE9, LSPA_CAMJ8;  A7H513, LSPA_CAMJD;  Q0PBE9, LSPA_CAMJE;  
A1VY81, LSPA_CAMJJ;  Q5HWA6, LSPA_CAMJR;  Q9AAA6, LSPA_CAUCR;  
B3PE13, LSPA_CELJU;  Q5L6Q8, LSPA_CHLAB;  Q3AQW9, LSPA_CHLCH;  
Q824E2, LSPA_CHLCV;  Q253G9, LSPA_CHLFF;  B3EEM7, LSPA_CHLL2;  
Q9PJY8, LSPA_CHLMU;  B3QQ42, LSPA_CHLP8;  B3ELA5, LSPA_CHLPB;  
A1BED5, LSPA_CHLPD;  Q9Z817, LSPA_CHLPN;  B0B7X8, LSPA_CHLT2;  
Q3KLU5, LSPA_CHLTA;  B0BC43, LSPA_CHLTB;  Q8KBH7, LSPA_CHLTE;  
O84413, LSPA_CHLTR;  Q7NS58, LSPA_CHRVO;  A8ALT5, LSPA_CITK8;  
Q97H98, LSPA_CLOAB;  Q182T8, LSPA_CLOD6;  A0Q072, LSPA_CLONN;  
Q894D4, LSPA_CLOTE;  A3DDW4, LSPA_CLOTH;  A9KEI7, LSPA_COXBN;  
A9NBM6, LSPA_COXBR;  Q83EC8, LSPA_COXBU;  B3R6E9, LSPA_CUPTR;  
B7KFK1, LSPA_CYAP7;  Q3Z6R4, LSPA_DEHE1;  A5FPV7, LSPA_DEHSB;  
Q3ZYT1, LSPA_DEHSC;  Q9RRU7, LSPA_DEIRA;  Q30ZF6, LSPA_DESDG;  
Q24TI7, LSPA_DESHY;  Q6AK46, LSPA_DESPS;  Q72AR4, LSPA_DESVH;  
A1VCU2, LSPA_DESVV;  A5EWT1, LSPA_DICNV;  A7ZHB6, LSPA_ECO24;  
B7MAE7, LSPA_ECO45;  Q8XA48, LSPA_ECO57;  B5YYB9, LSPA_ECO5E;  
B7NHD1, LSPA_ECO7I;  B7M0C3, LSPA_ECO8A;  B1XBF2, LSPA_ECODH;  
A7ZVX5, LSPA_ECOHS;  A1A775, LSPA_ECOK1;  Q0TLW4, LSPA_ECOL5;  
Q8FLB6, LSPA_ECOL6;  B1IRE8, LSPA_ECOLC;  P00804, LSPA_ECOLI;  
B7N7Q1, LSPA_ECOLU;  B6HZ22, LSPA_ECOSE;  B1LFV7, LSPA_ECOSM;  
Q1RGH5, LSPA_ECOUT;  A4W6E2, LSPA_ENT38;  P13514, LSPA_ENTAE;  
Q834D8, LSPA_ENTFA;  A7MIM2, LSPA_ENTS8;  B2VH02, LSPA_ERWT9;  
B7LVN3, LSPA_ESCF3;  Q14HT3, LSPA_FRAT1;  Q2A4Z5, LSPA_FRATH;  
B2SF87, LSPA_FRATM;  A0Q528, LSPA_FRATN;  Q0BNB6, LSPA_FRATO;  
Q5NGD1, LSPA_FRATT;  Q8RH46, LSPA_FUSNN;  Q5L0V0, LSPA_GEOKA;  
Q39YS9, LSPA_GEOMG;  Q747Y0, LSPA_GEOSL;  A4IM26, LSPA_GEOTN;  
Q7NPI3, LSPA_GLOVI;  Q7VPK5, LSPA_HAEDU;  Q4QLQ6, LSPA_HAEI8;  
A5UID8, LSPA_HAEIG;  P44975, LSPA_HAEIN;  Q0I1V9, LSPA_HAES1;  
B0UV09, LSPA_HAES2;  Q17VS8, LSPA_HELAH;  B6JPH7, LSPA_HELP2;  
Q1CV80, LSPA_HELPH;  Q9ZMZ3, LSPA_HELPJ;  B2UW72, LSPA_HELPS;  
P25178, LSPA_HELPY;  A6SW70, LSPA_JANMA;  B5Y234, LSPA_KLEP3;  
A6T4G1, LSPA_KLEP7;  Q043I1, LSPA_LACGA;  Q74JC2, LSPA_LACJO;  
Q9CGU5, LSPA_LACLA;  Q48729, LSPA_LACLM;  Q02ZK6, LSPA_LACLS;  
Q88W75, LSPA_LACPL;  Q1WTX7, LSPA_LACS1;  Q38X31, LSPA_LACSS;  
Q6AE72, LSPA_LEIXX;  B0S977, LSPA_LEPBA;  Q04QT4, LSPA_LEPBJ;  
Q053U5, LSPA_LEPBL;  B0SRR1, LSPA_LEPBP;  Q72PS8, LSPA_LEPIC;  
Q8F6H0, LSPA_LEPIN;  Q92AG4, LSPA_LISIN;  Q71YH2, LSPA_LISMF;  
Q8Y656, LSPA_LISMO;  A0AJU9, LSPA_LISW6;  A9W565, LSPA_METEP;  
A2SKB1, LSPA_METPP;  B1LSB3, LSPA_METRJ;  B0UDF9, LSPA_METS4;  
B0JFT3, LSPA_MICAN;  Q2RK54, LSPA_MOOTA;  A0QHM5, LSPA_MYCA1;  
P65263, LSPA_MYCBO;  A1KIW9, LSPA_MYCBP;  Q7NBQ3, LSPA_MYCGA;  
Q49401, LSPA_MYCGE;  Q9X7E7, LSPA_MYCLE;  Q8EWS0, LSPA_MYCPE;  
P75484, LSPA_MYCPN;  P65262, LSPA_MYCTU;  B2A2J1, LSPA_NATTJ;  
Q5FAF3, LSPA_NEIG1;  A9M1J8, LSPA_NEIM0;  P65264, LSPA_NEIMA;  
P65265, LSPA_NEIMB;  A1KS63, LSPA_NEIMF;  Q1QIP9, LSPA_NITHX;  
B2IU55, LSPA_NOSP7;  Q8ER40, LSPA_OCEIH;  A5CFG7, LSPA_ORITB;  
B3CS08, LSPA_ORITI;  P57959, LSPA_PASMU;  Q3A1R4, LSPA_PELCD;  
Q3B5L1, LSPA_PELLD;  B4SD15, LSPA_PELPB;  A5D178, LSPA_PELTS;  
Q4FPB0, LSPA_PELUB;  Q7N8X1, LSPA_PHOLL;  B1XW26, LSPA_POLNS;  
Q125P4, LSPA_POLSJ;  B2RI39, LSPA_PORG3;  Q7MUD1, LSPA_PORGI;  
A4SDK1, LSPA_PROVI;  Q15R05, LSPA_PSEA6;  A6VBU6, LSPA_PSEA7;  
Q02GB8, LSPA_PSEAB;  Q9HVM5, LSPA_PSEAE;  Q4K5U5, LSPA_PSEF5;  
P17942, LSPA_PSEFL;  Q3IEA1, LSPA_PSEHT;  A4XQV6, LSPA_PSEMY;  
Q3K6L6, LSPA_PSEPF;  Q88Q91, LSPA_PSEPK;  Q889E3, LSPA_PSESM;  
A1SZP2, LSPA_PSYIN;  Q0K799, LSPA_RALEH;  Q46XM6, LSPA_RALEJ;  
Q8XWL5, LSPA_RALSO;  Q98GR1, LSPA_RHILO;  Q92SJ3, LSPA_RHIME;  
Q7UF32, LSPA_RHOBA;  Q6N1M9, LSPA_RHOPA;  B3Q7Z4, LSPA_RHOPT;  
Q0SHT6, LSPA_RHOSR;  A8GNC3, LSPA_RICAH;  A8GVJ0, LSPA_RICB8;  
Q1RI47, LSPA_RICBR;  A8EZ20, LSPA_RICCK;  Q92I62, LSPA_RICCN;  
Q4ULU0, LSPA_RICFE;  Q9ZDC4, LSPA_RICPR;  Q68WX1, LSPA_RICTY;  
B5F725, LSPA_SALA4;  A9MR45, LSPA_SALAR;  Q57TL4, LSPA_SALCH;  
B5FHE1, LSPA_SALDC;  B5R1N7, LSPA_SALEP;  B5RG82, LSPA_SALG2;  
B4TIE6, LSPA_SALHS;  B4T6H3, LSPA_SALNS;  Q5PDL8, LSPA_SALPA;  
B5BLL1, LSPA_SALPK;  B4TWN7, LSPA_SALSV;  Q8Z9N1, LSPA_SALTI;  
Q8ZRY9, LSPA_SALTY;  O52213, LSPA_SERMA;  A8G9L5, LSPA_SERP5;  
A1S426, LSPA_SHEAM;  A3D1G6, LSPA_SHEB5;  A6WKD5, LSPA_SHEB8;  
A9L4U8, LSPA_SHEB9;  B0TJB0, LSPA_SHEHH;  A3QBX3, LSPA_SHELP;  
Q8EBI5, LSPA_SHEON;  A8H1H4, LSPA_SHEPA;  B8CSC0, LSPA_SHEPW;  
A8FSI3, LSPA_SHESH;  Q0HFZ0, LSPA_SHESM;  Q0HS83, LSPA_SHESR;  
B1KIT6, LSPA_SHEWM;  B2U246, LSPA_SHIB3;  Q326J6, LSPA_SHIBS;  
Q32K70, LSPA_SHIDS;  Q0T8G7, LSPA_SHIF8;  Q83MH1, LSPA_SHIFL;  
Q3Z5Y3, LSPA_SHISS;  Q2NVY5, LSPA_SODGM;  Q01VL4, LSPA_SOLUE;  
Q1GQK7, LSPA_SPHAL;  A5VCW2, LSPA_SPHWW;  A7X1E3, LSPA_STAA1;  
A6U115, LSPA_STAA2;  Q2FHP2, LSPA_STAA3;  Q2FZ79, LSPA_STAA8;  
A5IS81, LSPA_STAA9;  Q2YXH2, LSPA_STAAB;  Q5HGN6, LSPA_STAAC;  
A6QG97, LSPA_STAAE;  P65266, LSPA_STAAM;  P65267, LSPA_STAAN;  
Q6GHN9, LSPA_STAAR;  Q6GA17, LSPA_STAAS;  A8Z3N3, LSPA_STAAT;  
P31024, LSPA_STAAU;  P65268, LSPA_STAAW;  Q59835, LSPA_STACT;  
Q5HPZ5, LSPA_STAEQ;  Q8CPK0, LSPA_STAES;  Q4L5P8, LSPA_STAHJ;  
Q3K0E6, LSPA_STRA1;  Q8E4G5, LSPA_STRA3;  Q8DYV7, LSPA_STRA5;  
Q82AC7, LSPA_STRAW;  Q9S2X7, LSPA_STRCO;  B1W0K0, LSPA_STRGG;  
Q8DUQ0, LSPA_STRMU;  Q9A0D2, LSPA_STRP1;  Q8K7Y7, LSPA_STRP3;  
Q5XCS3, LSPA_STRP6;  Q8P1G4, LSPA_STRP8;  Q1JCF3, LSPA_STRPB;  
Q1JMD2, LSPA_STRPC;  Q1JHH8, LSPA_STRPD;  Q1J798, LSPA_STRPF;  
A2RF66, LSPA_STRPG;  Q48U75, LSPA_STRPM;  Q8DQ64, LSPA_STRR6;  
Q5M0X5, LSPA_STRT1;  Q5M5G2, LSPA_STRT2;  Q03LU4, LSPA_STRTD;  
Q30NW9, LSPA_SULDN;  A6Q6B7, LSPA_SULNB;  B2V758, LSPA_SULSY;  
Q67Q16, LSPA_SYMTH;  Q2LTG5, LSPA_SYNAS;  Q7U7A6, LSPA_SYNPX;  
A5GTI3, LSPA_SYNR3;  Q0AXF8, LSPA_SYNWW;  P73540, LSPA_SYNY3;  
Q8DGA3, LSPA_THEEB;  Q8R9R0, LSPA_THETN;  B5YJT2, LSPA_THEYD;  
Q73JG0, LSPA_TREDE;  O83943, LSPA_TREPA;  Q83I41, LSPA_TROW8;  
Q83G22, LSPA_TROWT;  A5F8Z4, LSPA_VIBC3;  Q9KU46, LSPA_VIBCH;  
A7MTD7, LSPA_VIBHB;  Q87S89, LSPA_VIBPA;  Q8DES8, LSPA_VIBVU;  
Q7MNM7, LSPA_VIBVY;  Q8D2R1, LSPA_WIGBR;  Q7M9M1, LSPA_WOLSU;  
Q8PN18, LSPA_XANAC;  Q3BW41, LSPA_XANC5;  Q4US41, LSPA_XANC8;  
Q8PBG5, LSPA_XANCP;  Q2P5A9, LSPA_XANOM;  B2STC5, LSPA_XANOP;  
Q5H2E0, LSPA_XANOR;  B2I6V1, LSPA_XYLF2;  Q9PAS8, LSPA_XYLFA;  
B0U3Q8, LSPA_XYLFM;  Q87BL6, LSPA_XYLFT;  A1JJE2, LSPA_YERE8;  
A7FMD6, LSPA_YERP3;  Q1C0J2, LSPA_YERPA;  B2K3M7, LSPA_YERPB;  
Q8ZIL9, LSPA_YERPE;  A9R007, LSPA_YERPG;  Q1CMV0, LSPA_YERPN;  
A4TQF2, LSPA_YERPP;  Q66ES3, LSPA_YERPS;  B1JKZ7, LSPA_YERPY;  

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