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NiceZyme View of ENZYME: EC 3.4.23.1

Official Name
Pepsin A.
Alternative Name(s)
Pepsin.
Reaction catalysed
Preferential cleavage: hydrophobic, preferably aromatic, residues in P1 and P1' positions. Cleaves 1-Phe-|-Val-2, 4-Gln-|-His-5, 13-Glu-|-Ala-14, 14-Ala-|-Leu-15, 15-Leu-|-Tyr-16, 16-Tyr-|-Leu-17, 23-Gly-|-Phe-24, 24-Phe-|-Phe-25 and 25-Phe-|-Tyr-26 bonds in the B chain of insulin
Comment(s)
  • The predominant endopeptidase in the gastric juice of vertebrates, formed from pepsinogen A by limited proteolysis.
  • Belongs to peptidase family A1.
  • Formerly EC 3.4.4.1.
Cross-references
PROSITEPDOC00128
BRENDA3.4.23.1
PUMA23.4.23.1
PRIAM enzyme-specific profiles3.4.23.1
KEGG Ligand Database for Enzyme Nomenclature3.4.23.1
IUBMB Enzyme Nomenclature3.4.23.1
IntEnz3.4.23.1
MEDLINEFind literature relating to 3.4.23.1
MetaCyc3.4.23.1

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