| Official Name |
|---|
| Peptidase 1 (mite).
|
| Alternative Name(s) |
|---|
| Allergen Der p 1. |
| Endopeptidase 1 (mite). |
| Major mite fecal allergen Der p 1. |
| Reaction catalysed |
|---|
| Broad endopeptidase specificity |
| Comment(s) |
|---|
- This enzyme, derived from the house dust mite, is a major component
of the allergic immune response.
- The substrate specificity of this enzyme is not altogether clear; it
cleaves the low-affinity IgE receptor CD23 at 298-Glu-|-Ser-299 and
155-Ser-|-Ser-156.
- It also cleaves the pulmonary structural proteins occludin and
claudin at Leu-|-Leu, Asp-|-Leu and at Gly-|-Thr bonds, and it can
also cleave the alpha subunit of the interleukin-2 (IL-2) receptor
(CD25).
- Using a positional scanning combinatorial library, it was found that
the major substrate-specificity determinant is for Ala in the P2
position.
- The enzyme shows only a slight preference for basic amino acids in
the P1 and P3 positions and a preference for aliphatic amino acids
such as Ile, Pro, Val, Leu and norleucine in the P4 position.
- Belongs to peptidase family C1.
|
| Cross-references |
|---|
| BRENDA | 3.4.22.65 |
| PUMA2 | 3.4.22.65 |
| PRIAM enzyme-specific profiles | 3.4.22.65 |
| KEGG Ligand Database for Enzyme Nomenclature | 3.4.22.65 |
| IUBMB Enzyme Nomenclature | 3.4.22.65 |
| IntEnz | 3.4.22.65 |
| MEDLINE | Find literature relating to 3.4.22.65 |
| MetaCyc | 3.4.22.65 |
| UniProtKB/Swiss-Prot |
|
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