| Official Name |
|---|
| Caspase-8.
|
| Alternative Name(s) |
|---|
| Apoptotic cysteine protease. |
| Apoptotic protease Mch-5. |
| CAP4. |
| CASP-8. |
| FADD-homologous ICE/CED-3-like protease. |
| FADD-like ICE. |
| FLICE. |
| ICE-like apoptotic protease 5. |
| MACH. |
| Mammalian Ced-3 homolog 5. |
| Mch5. |
| MORT1-associated CED-3 homolog. |
| Reaction catalysed |
|---|
| Strict requirement for Asp at position P1 and has a preferred cleavage sequence of (Leu/Asp/Val)-Glu-Thr-Asp-|-(Gly/Ser/Ala) |
| Comment(s) |
|---|
- Caspase-8 is an initiator caspase, as are caspase-2 (EC 3.4.22.55),
caspase-9 (EC 3.4.22.62) and caspase-10 (EC 3.4.22.63).
- Apical activator of the extrinsic (death receptor) apoptosis pathway,
triggered by death receptor ligation.
- Contains two tandem death effector domains (DEDs) in its N-terminal
prodomain, which play a role in procaspase activation.
- Linked to cell surface death receptors such as Fas.
- When Fas is aggregated by the Fas ligand, procaspase-8 is recruited
to the death receptor where it is activated.
- Has a preference for Glu at P3 and prefers small residues, such as
Gly, Ser and Ala at the P1' position.
- Has very broad P4 specificity, tolerating substrates with Asp, Val or
Leu in this position.
- Endogenous substrates for caspase-8 include procaspase-3, the pro-
apoptotic Bcl-2 family member Bid, RIP, PAK2 and the caspase-8
activity modulator FLIP(L).
- Belongs to peptidase family C14.
|
| Cross-references |
|---|
| BRENDA | 3.4.22.61 |
| PUMA2 | 3.4.22.61 |
| PRIAM enzyme-specific profiles | 3.4.22.61 |
| KEGG Ligand Database for Enzyme Nomenclature | 3.4.22.61 |
| IUBMB Enzyme Nomenclature | 3.4.22.61 |
| IntEnz | 3.4.22.61 |
| MEDLINE | Find literature relating to 3.4.22.61 |
| MetaCyc | 3.4.22.61 |
| UniProtKB/Swiss-Prot |
|
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