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NiceZyme View of ENZYME: EC 3.4.22.45

Official Name
Helper-component proteinase.
Alternative Name(s)
HC-Pro.
Reaction catalysed
Hydrolyzes a Gly-|-Gly bond at its own C-terminus, commonly in the sequence -Tyr-Xaa-Val-Gly-|-Gly, in the processing of the potyviral polyprotein
Comment(s)
  • Known from many potyviruses.
  • The helper component-proteinase of the tobacco etch virus is a multifunctional protein with several known activities.
  • The N-terminal region is required for aphid transmission and efficient genome amplification, the central region is required for long-distance movement in plants, and the C-terminal domain has cysteine endopeptidase activity.
  • Belongs to peptidase family C6.
Cross-references
BRENDA3.4.22.45
PUMA23.4.22.45
PRIAM enzyme-specific profiles3.4.22.45
KEGG Ligand Database for Enzyme Nomenclature3.4.22.45
IUBMB Enzyme Nomenclature3.4.22.45
IntEnz3.4.22.45
MEDLINEFind literature relating to 3.4.22.45
MetaCyc3.4.22.45
UniProtKB/Swiss-Prot
Q65329, POL2_BAMMA;  P89684, POL2_BAMMN;  Q65657, POL2_BAMMU;  
Q01365, POL2_BAYMG;  Q01207, POL2_BAYMJ;  Q65399, POLG_BCMNN;  
Q65730, POLG_BSTV1;  Q6XW15, POLG_BTMV;  P17765, POLG_BYMV;  
P31999, POLG_LMV0;  P89876, POLG_LMVE;  Q01500, POLG_PEMVC;  
O56075, POLG_PEMVM;  P13529, POLG_PPVD;  P17766, POLG_PPVNA;  
P17767, POLG_PPVRA;  Q84934, POLG_PPVSK;  Q01901, POLG_PRSVH;  
P29152, POLG_PSBMV;  Q85197, POLG_PVMA;  P22601, POLG_PVYC;  
Q02963, POLG_PVYHU;  P18247, POLG_PVYN;  P22602, POLG_PVYO;  
Q90069, POLG_SBMVG;  P21231, POLG_SBMVN;  P04517, POLG_TEV;  
P89509, POLG_TUMVJ;  Q02597, POLG_TUMVQ;  P09814, POLG_TVMV;  
P18479, POLG_ZYMVC;  Q89330, POLG_ZYMVR;  O36979, POLG_ZYMVS;  

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