ID   3.4.22.40
DE   Bleomycin hydrolase.
AN   Aminopeptidase C (Lactococcus lactis).
CA   Inactivates bleomycin B2 (a cytotoxic glycometallopeptide) by hydrolysis
CA   of a carboxyamide bond of beta-aminoalanine, but also shows general
CA   aminopeptidase activity. The specificity varies somewhat with source,
CA   but amino acid arylamides of Met, Leu and Ala are preferred.
CC   -!- The active sites are on the walls of a central channel through the
CC       molecule, and access of substrate molecules to them is obstructed by
CC       this and by the C-terminus of each polypeptide chain.
CC   -!- Bleomycin can scarcely be the natural substrate, and there are
CC       reports of limited endopeptidase activity.
CC   -!- Known from bacteria as well as eukaryotic organisms.
CC   -!- Hydrolase H from chicken muscle has many similarities to bleomycin
CC       hydrolase, but hydrolyzes Ph-CO-Arg-2-naphthylamine as well as
CC       aminopeptidase substrates.
CC   -!- Belongs to peptidase family C1.
PR   PROSITE; PDOC00126;
DR   Q01532, BLH1_YEAST ;  P87362, BLMH_CHICK ;  Q13867, BLMH_HUMAN ;
DR   Q8R016, BLMH_MOUSE ;  P13019, BLMH_RABIT ;  P70645, BLMH_RAT   ;
DR   Q48543, PEPC_LACDL ;  Q10744, PEPC_LACHE ;  Q9CEG3, PEPC_LACLA ;
DR   Q04723, PEPC_LACLC ;  Q928V0, PEPC_LISIN ;  O69192, PEPC_LISMO ;
DR   Q56115, PEPC_STRTR ;
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