| Official Name |
|---|
| Caspase-1.
|
| Alternative Name(s) |
|---|
| Interleukin 1-beta converting enzyme. |
| Interleukin 1-beta-converting endopeptidase. |
| Interleukin-1 beta convertase precursor. |
| Interleukin-1-beta convertase. |
| Pro-interleukin 1-beta proteinase. |
| Prointerleukin 1-beta protease. |
| Reaction catalysed |
|---|
| Strict requirement for an Asp residue at position P1 and has a preferred cleavage sequence of Tyr-Val-Ala-Asp-|- |
| Comment(s) |
|---|
- Part of the family of inflammatory-caspases, which also includes
caspase-4 (EC 3.4.22.57) and caspase-5 (EC 3.4.22.58) in humans and
caspase-11 (EC 3.4.22.64), caspase-12, caspase-13 and caspase-14 in
mice.
- Contains a caspase-recruitment domain (CARD) in its N-terminal
prodomain, which plays a role in procaspase activation.
- Cleaves pro-interleukin-1-beta (pro-IL-1-beta) to form mature IL-1-
beta, a potent mediator of inflammation.
- Also activates the proinflammatory cytokine, IL-18, which is also
known as interferon-gamma-inducing factor.
- Inhibited by Ac-Tyr-Val-Ala-Asp-CHO.
- Caspase-11 plays a critical role in the activation of caspase-1 in
mice whereas caspase-4 enhances its activation in humans.
- Belongs to peptidase family C14.
|
| Cross-references |
|---|
| PROSITE | PDOC00864 |
| BRENDA | 3.4.22.36 |
| PUMA2 | 3.4.22.36 |
| PRIAM enzyme-specific profiles | 3.4.22.36 |
| KEGG Ligand Database for Enzyme Nomenclature | 3.4.22.36 |
| IUBMB Enzyme Nomenclature | 3.4.22.36 |
| IntEnz | 3.4.22.36 |
| MEDLINE | Find literature relating to 3.4.22.36 |
| MetaCyc | 3.4.22.36 |
| UniProtKB/Swiss-Prot |
|
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