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ENZYME

ENZYME entry: EC 3.4.22.1

Accepted Name
cathepsin B
Alternative Name(s)
cathepsin B1
Reaction catalysed
Hydrolysis of proteins with broad specificity for peptide bonds. Preferentially cleaves -Arg-Arg-|-Xaa bonds in small molecule substrates (thus differing from cathepsin L). In addition to being an endopeptidase, shows peptidyl-dipeptidase activity, liberating C-terminal dipeptides
Comment(s)
  • An intracellular (lysosomal) enzyme.
  • Belongs to peptidase family C1.
Cross-references
BRENDA3.4.22.1
EC2PDB3.4.22.1
ExplorEnz3.4.22.1
PRIAM enzyme-specific profiles3.4.22.1
KEGG Ligand Database for Enzyme Nomenclature3.4.22.1
IUBMB Enzyme Nomenclature3.4.22.1
IntEnz3.4.22.1
MEDLINEFind literature relating to 3.4.22.1
MetaCyc3.4.22.1
Rhea expert-curated reactions3.4.22.1
UniProtKB/Swiss-Prot
P07688, CATB_BOVINP43233, CATB_CHICKP81494, CATB_COTJA
P07858, CATB_HUMANQ4R5M2, CATB_MACFAP10605, CATB_MOUSE
A1E295, CATB_PIGQ5R6D1, CATB_PONABP00787, CATB_RAT
P83205, CATB_SHEEPQ54QD9, CTSB_DICDI

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