| Official Name |
|---|
| Hepacivirin.
|
| Alternative Name(s) |
|---|
| Cpro-2. |
| Hepatitis C virus NS3 serine proteinase. |
| Reaction catalysed |
|---|
| Hydrolysis of four peptide bonds in the viral precursor polyprotein, commonly with Asp or Glu in the P6 position, Cys or Thr in P1 and Ser or Ala in P1' |
| Comment(s) |
|---|
- Encoded by the genome of the viruses of the hepatitis C group,
and contributes to the maturation of the precursor polyproteins.
- The enzyme is greatly activated by binding of the 54-residue NS4A
'cofactor' protein also derived from the viral polyprotein.
- Belongs to peptidase family S29.
|
| Cross-references |
|---|
| BRENDA | 3.4.21.98 |
| PUMA2 | 3.4.21.98 |
| PRIAM enzyme-specific profiles | 3.4.21.98 |
| KEGG Ligand Database for Enzyme Nomenclature | 3.4.21.98 |
| IUBMB Enzyme Nomenclature | 3.4.21.98 |
| IntEnz | 3.4.21.98 |
| MEDLINE | Find literature relating to 3.4.21.98 |
| MetaCyc | 3.4.21.98 |
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