| Accepted Name |
|---|
| Proprotein convertase 2.
|
| Alternative Name(s) |
|---|
| NEC 2. |
| Neuroendocrine convertase 2. |
| PC(2). |
| Prohormone convertase II. |
| Reaction catalysed |
|---|
| Release of protein hormones and neuropeptides from their precursors, generally by hydrolysis of -Lys-Arg-|- bonds |
| Comment(s) |
|---|
- A calcium dependent enzyme, maximally active at about pH 5.5.
- Specificity is broader than that of prohormone convertase 1.
- Substrates include pro-opiomelanocortin, proenkephalin, prodynorphin,
proinsulin and proluteinizing-hormone-releasing hormone.
- Unlike prohormone convertase 1, does not cleave prorenin or
prosomatostatin.
- Usually processing of prodynorphin occurs at a bond in which P2 is
Thr.
- Present in the regulated secretory pathway of neuroendocrine cells,
commonly actin co-operatively with prohormone convertase 1.
- Belongs to peptidase family S8.
|
| Cross-references |
|---|
| PROSITE | PDOC00125 |
| BRENDA | 3.4.21.94 |
| EC2PDB | 3.4.21.94 |
| PRIAM enzyme-specific profiles | 3.4.21.94 |
| KEGG Ligand Database for Enzyme Nomenclature | 3.4.21.94 |
| IUBMB Enzyme Nomenclature | 3.4.21.94 |
| IntEnz | 3.4.21.94 |
| MEDLINE | Find literature relating to 3.4.21.94 |
| MetaCyc | 3.4.21.94 |
| UniProtKB/Swiss-Prot |
|
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