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ENZYME

ENZYME entry: EC 3.4.21.93

Accepted Name
proprotein convertase 1
Alternative Name(s)
NEC 1
neuroendocrine convertase 1
PC1
prohormone convertase I
Reaction catalysed
Release of protein hormones, neuropeptides and renin from their precursors, generally by hydrolysis of -Lys-Arg-|- bonds
Comment(s)
  • A calcium dependent enzyme, maximally active at about pH 5.5.
  • Substrates include pro-opiomelanocortin, prorenin, proenkephalin, prodynorphin, prosomatostatin and proinsulin.
  • Unlike prohormone convertase 2, does not cleave proluteinizing- hormone-releasing hormone.
  • Usually processing of prodynorphin occurs at a bond in which P2 is Thr.
  • Present in the regulated secretory pathway of neuroendocrine cells, commonly actin co-operatively with prohormone convertase 2.
  • Belongs to peptidase family S8.
Cross-references
BRENDA3.4.21.93
EC2PDB3.4.21.93
ExplorEnz3.4.21.93
PRIAM enzyme-specific profiles3.4.21.93
KEGG Ligand Database for Enzyme Nomenclature3.4.21.93
IUBMB Enzyme Nomenclature3.4.21.93
IntEnz3.4.21.93
MEDLINEFind literature relating to 3.4.21.93
MetaCyc3.4.21.93
Rhea expert-curated reactions3.4.21.93
UniProtKB/Swiss-Prot
Q9GLR1, NEC1_BOVINP29120, NEC1_HUMANP63239, NEC1_MOUSE
P63240, NEC1_MUSCOP28840, NEC1_RAT

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