| Official Name |
|---|
| Alternative-complement-pathway C3/C5 convertase.
|
| Alternative Name(s) |
|---|
| C3 convertase. |
| C3 proactivator. |
| C5 convertase. |
| Complement component C3/C5 convertase (alternative). |
| Complement factor B. |
| Properdin factor B. |
| Reaction catalysed |
|---|
| Cleavage of Arg-|-Ser bond in complement component C3 alpha-chain to yield C3a and C3b, and Arg-|-Xaa bond in complement component C5 alpha-chain to yield C5a and C5b |
| Comment(s) |
|---|
- A bimolecular complex of complement fragment Bb with either C3b or
cobra venom factor; Bb contains the active site.
- Bb is formed by cleavage of proenzyme factor B by factor D.
- Cleavage of complement component C5 requires additional C3b which
binds C5 and renders it susceptible to cleavage by C3b,Bb complex.
- C3b,Bb is stabilized in plasma by factor P.
- Belongs to peptidase family S1.
|
| Cross-references |
|---|
| Biochemical Pathways; map number(s) | R1 |
| PROSITE | PDOC00124 |
| BRENDA | 3.4.21.47 |
| PUMA2 | 3.4.21.47 |
| PRIAM enzyme-specific profiles | 3.4.21.47 |
| KEGG Ligand Database for Enzyme Nomenclature | 3.4.21.47 |
| IUBMB Enzyme Nomenclature | 3.4.21.47 |
| IntEnz | 3.4.21.47 |
| MEDLINE | Find literature relating to 3.4.21.47 |
| MetaCyc | 3.4.21.47 |
| UniProtKB/Swiss-Prot |
|
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