ExPASy Proteomics Server

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NiceZyme View of ENZYME: EC 3.4.21.41

Accepted Name

Complement subcomponent C1r.

Reaction catalysed

Selective cleavage of Lys(or Arg)-|-Ile bond in complement subcomponent C1s to form the active form of C1s (EC 3.4.21.42)

Comment(s)

Activates C1s by proteolytic cleavage so that it can, in turn, activate C2 and C4.
Activated from proenzyme C1r in plasma by autocatalytic mechanism during activation of the complement system by the 'classical' route.
Belongs to peptidase family S1.

Cross-references

Biochemical Pathways; map number(s)

PROSITE

BRENDA

EC2PDB

PRIAM enzyme-specific profiles

KEGG Ligand Database for Enzyme Nomenclature

IUBMB Enzyme Nomenclature

IntEnz

MEDLINE

MetaCyc

UniProtKB/Swiss-Prot

Q8CG16, C1RA_MOUSE;	Q8CFG9, C1RB_MOUSE;	P00736, C1R_HUMAN;
Q4R577, C1R_MACFA;	Q5R1W3, C1R_PANTR;	Q5R544, C1R_PONAB;