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ENZYME entry: EC 3.4.21.104

Accepted Name
Mannan-binding lectin-associated serine protease-2.
Alternative Name(s)
Mannan-binding lectin-associated serine peptidase 2.
Mannose-binding lectin-associated serine protease-2.
MASP-2.
MASP2.
MBP-associated serine protease-2.
Reaction catalysed
Selective cleavage after Arg-223 in complement component C2 (-Ser-Leu-Gly-Arg-|-Lys-Ile-Gln-Ile) and after Arg-76 in complement component C4 (-Gly-Leu-Gln-Arg-|-Ala-Leu-Glu-Ile)
Comment(s)
  • Mannan-binding lectin (MBL) recognizes patterns of neutral carbohydrates, such as mannose and N-acetylglucosamine, on a wide range of microbial surfaces and is able to initiate activation of the lectin pathway of complement.
  • Displays C1s-like esterolytic activity (cf. EC 3.4.21.42).
  • It also cleaves C4 and C2 with efficiencies that are relatively higher than those of EC 3.4.21.42.
  • Belongs to peptidase family S1A.
Cross-references
PROSITEPDOC00124
BRENDA3.4.21.104
EC2PDB3.4.21.104
PRIAM enzyme-specific profiles3.4.21.104
KEGG Ligand Database for Enzyme Nomenclature3.4.21.104
IUBMB Enzyme Nomenclature3.4.21.104
IntEnz3.4.21.104
MEDLINEFind literature relating to 3.4.21.104
MetaCyc3.4.21.104
UniProtKB/Swiss-Prot
O00187, MASP2_HUMAN;  Q91WP0, MASP2_MOUSE;  Q9JJS8, MASP2_RAT;  

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