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ENZYME

ENZYME entry: EC 3.4.17.20

Accepted Name
carboxypeptidase U
Alternative Name(s)
arginine carboxypeptidase
carboxypeptidase B2
carboxypeptidase R
plasma carboxypeptidase B
TAFI
thrombin-activatable fibrinolysis inhibitor
Reaction catalysed
Release of C-terminal Arg and Lys from a polypeptide
Comment(s)
  • Pro-carboxypeptidase U in plasma is activated by thrombin or plasmin during clotting to form the unstable carboxypeptidase U.
  • Activity similar to that of the more stable lysine carboxypeptidase, except no preference is shown for Lys over Arg.
  • Belongs to peptidase family M14.
Cross-references
BRENDA3.4.17.20
EC2PDB3.4.17.20
ExplorEnz3.4.17.20
PRIAM enzyme-specific profiles3.4.17.20
KEGG Ligand Database for Enzyme Nomenclature3.4.17.20
IUBMB Enzyme Nomenclature3.4.17.20
IntEnz3.4.17.20
MEDLINEFind literature relating to 3.4.17.20
MetaCyc3.4.17.20
Rhea expert-curated reactions3.4.17.20
UniProtKB/Swiss-Prot
Q2KIG3, CBPB2_BOVINQ96IY4, CBPB2_HUMANQ9JHH6, CBPB2_MOUSE
Q9EQV9, CBPB2_RAT

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