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ENZYME

ENZYME entry: EC 3.4.13.22

Accepted Name
D-Ala-D-Ala dipeptidase
Alternative Name(s)
D-alanyl-D-alanine dipeptidase
Reaction catalysed
D-alanyl-D-alanine + H2O <=> 2 D-alanine
Comment(s)
  • Protects Enterococcus faecium from the antibiotic vancomycin, which can bind to the -D-Ala-D-Ala sequence at the C-terminus of the peptidoglycan pentapeptide.
  • Reduces the availability of the free dipeptide D-Ala-D-Ala, which is the precursor for this pentapeptide sequence, allowing D-Ala-(R)- lactate (for which vancomycin has much less affinity) to be added to the cell wall instead.
  • The enzyme is stereospecific, as L-Ala-L-Ala, D-Ala-L-Ala and L-Ala- D-Ala are not substrates.
  • Belongs to peptidase family M15.
Cross-references
BRENDA3.4.13.22
EC2PDB3.4.13.22
ExplorEnz3.4.13.22
PRIAM enzyme-specific profiles3.4.13.22
KEGG Ligand Database for Enzyme Nomenclature3.4.13.22
IUBMB Enzyme Nomenclature3.4.13.22
IntEnz3.4.13.22
MEDLINEFind literature relating to 3.4.13.22
MetaCyc3.4.13.22
Rhea expert-curated reactions3.4.13.22
UniProtKB/Swiss-Prot
P77790, DDPX_ECOLIP74268, DDPX_SYNY3Q47749, VANX_ENTFA
Q06241, VANX_ENTFCQ9XAK6, VANX_STRCO

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