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NiceZyme View of ENZYME: EC 3.4.11.5

Accepted Name
Prolyl aminopeptidase.
Alternative Name(s)
Cytosol aminopeptidase V.
Pro-X aminopeptidase.
Proline aminopeptidase.
Proline iminopeptidase.
Reaction catalysed
Release of N-terminal proline from a peptide
Cofactor(s)
Manganese.
Comment(s)
  • Present in the cytosol of mammalian and microbial cells.
  • In contrast to the mammalian form, the bacterial form of the enzyme hydrolyzes both polyproline and prolyl-2-naphthylamide.
  • The mammalian enzyme, which is not specific for prolyl bonds, is possibly identical with EC 3.4.11.1.
  • Belongs to peptidase family S33.
  • Formerly EC 3.4.1.4.
Cross-references
PROSITEPDOC00548
BRENDA3.4.11.5
EC2PDB3.4.11.5
PRIAM enzyme-specific profiles3.4.11.5
KEGG Ligand Database for Enzyme Nomenclature3.4.11.5
IUBMB Enzyme Nomenclature3.4.11.5
IntEnz3.4.11.5
MEDLINEFind literature relating to 3.4.11.5
MetaCyc3.4.11.5
UniProtKB/Swiss-Prot
P30184, AMPL1_ARATH;  Q2QSB9, AMPL1_ORYSJ;  Q10712, AMPL1_SOLLC;  
Q8RX72, AMPL2_ARATH;  Q6K669, AMPL2_ORYSJ;  Q42876, AMPL2_SOLLC;  
Q944P7, AMPL3_ARATH;  P00727, AMPL_BOVIN;  Q5V9F0, AMPL_DICDI;  
P28838, AMPL_HUMAN;  Q9CPY7, AMPL_MOUSE;  P28839, AMPL_PIG;  
Q68FS4, AMPL_RAT;  P31427, AMPL_SOLTU;  Q5XGB9, AMPL_XENTR;  
P46547, PIP_AERSO;  P93732, PIP_ARATH;  P46541, PIP_BACCO;  
P46544, PIP_LACDE;  P46542, PIP_LACDL;  P52278, PIP_LACHE;  
P47266, PIP_MYCGE;  P75092, PIP_MYCPN;  P42786, PIP_NEIGO;  
Q9JUV1, PIP_NEIMA;  Q9JZR6, PIP_NEIMB;  O83041, PIP_PLEBO;  
O32449, PIP_SERMA;  Q9S2L4, PIP_STRCO;  Q97UA2, PIP_SULSO;  
P96084, PIP_THEAC;  Q97A76, PIP_THEVO;  P52279, PIP_XANCI;  
Q9PD69, PIP_XYLFA;  Q87DF8, PIP_XYLFT;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.4.11.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.4.-.-
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