| Accepted Name |
|---|
| Leukotriene-A(4) hydrolase.
|
| Alternative Name(s) |
|---|
| Leukotriene A(4) hydrolase. |
| Leukotriene-A4 hydrolase. |
| LTA-4 hydrolase. |
| Reaction catalysed |
|---|
| (7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa-7,9,11,14-tetraenoate + H(2)O <=> (6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate |
| Cofactor(s) |
|---|
| Zinc.
|
| Comment(s) |
|---|
- A bifunctional zinc metalloprotease that displays both epoxide
hydrolase and aminopeptidase activities.
- It preferentially cleaves tripeptides at an arginyl bond, with
dipeptides and tetrapeptides being poorer substrates.
- It also converts leukotriene A(4) into leukotriene B(4), unlike
EC 3.2.2.10 which converts leukotriene A(4) into 5,6-dihydroxy-
7,9,11,14-eicosatetraenoic acid.
|
| Cross-references |
|---|
| Biochemical Pathways; map number(s) | T6 |
| PROSITE | PDOC00129 |
| BRENDA | 3.3.2.6 |
| EC2PDB | 3.3.2.6 |
| PRIAM enzyme-specific profiles | 3.3.2.6 |
| KEGG Ligand Database for Enzyme Nomenclature | 3.3.2.6 |
| IUBMB Enzyme Nomenclature | 3.3.2.6 |
| IntEnz | 3.3.2.6 |
| MEDLINE | Find literature relating to 3.3.2.6 |
| MetaCyc | 3.3.2.6 |
| UniProtKB/Swiss-Prot |
| A5DME6, LKA41_PICGU; | A3LRX6, LKA41_PICST; | A5DGF3, LKA42_PICGU; |
| A3LQI7, LKA42_PICST; | A6RCT2, LKHA4_AJECN; | Q75B10, LKHA4_ASHGO; |
| A1CSI2, LKHA4_ASPCL; | Q4X265, LKHA4_ASPFU; | A2QKF8, LKHA4_ASPNC; |
| Q2TZ99, LKHA4_ASPOR; | Q0CFY9, LKHA4_ASPTN; | A6SAG8, LKHA4_BOTFB; |
| Q3SZH7, LKHA4_BOVIN; | Q59NB8, LKHA4_CANAL; | Q6FTM0, LKHA4_CANGA; |
| P19602, LKHA4_CAVPO; | Q2GY21, LKHA4_CHAGB; | Q6S9C8, LKHA4_CHILA; |
| Q1DVD1, LKHA4_COCIM; | Q6BW21, LKHA4_DEBHA; | P52922, LKHA4_DICDI; |
| Q5B0W8, LKHA4_EMENI; | P09960, LKHA4_HUMAN; | Q6CLD3, LKHA4_KLULA; |
| A5DSS4, LKHA4_LODEL; | A4QUC1, LKHA4_MAGGR; | P24527, LKHA4_MOUSE; |
| A1DG68, LKHA4_NEOFI; | Q7S785, LKHA4_NEUCR; | Q0U653, LKHA4_PHANO; |
| P30349, LKHA4_RAT; | O94544, LKHA4_SCHPO; | A7EJL9, LKHA4_SCLS1; |
| A7THG7, LKHA4_VANPO; | Q6C3E5, LKHA4_YARLI; | A6ZS33, LKHA4_YEAS7; |
| Q10740, LKHA4_YEAST; |
|
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