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NiceZyme View of ENZYME: EC 3.1.4.53

Accepted Name
3',5'-cyclic-AMP phosphodiesterase.
Alternative Name(s)
cAMP-specific PDE.
cAMP-specific phosphodiesterase.
Reaction catalysed
Adenosine 3',5'-cyclic phosphate + H(2)O <=> adenosine 5'-phosphate
Comment(s)
  • A class I phosphodiesterase that is specific for 3',5'-cAMP and does not hydrolyze other nucleoside 3',5'-cyclic phosphates such as cGMP (cf. EC 3.1.4.17 and EC 3.1.4.35).
  • It is involved in modulation of the levels of cAMP, which is a mediator in the processes of cell transformation and proliferation.
Cross-references
BRENDA3.1.4.53
EC2PDB3.1.4.53
PRIAM enzyme-specific profiles3.1.4.53
KEGG Ligand Database for Enzyme Nomenclature3.1.4.53
IUBMB Enzyme Nomenclature3.1.4.53
IntEnz3.1.4.53
MEDLINEFind literature relating to 3.1.4.53
MetaCyc3.1.4.53
UniProtKB/Swiss-Prot
P12019, PDE1_DICDI;  Q23917, PDE2_DICDI;  Q86H13, PDE4_DICDI;  
Q8MM62, PDE6_DICDI;  Q54HY0, PDE7_DICDI;  

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