| Official Name |
|---|
| Acireductone synthase.
|
| Alternative Name(s) |
|---|
| E-1 enolase-phosphatase. |
| Reaction catalysed |
|---|
| 5-(methylthio)-2,3-dioxopentyl phosphate + H(2)O <=> 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + phosphate |
| Comment(s) |
|---|
- This bifunctional enzyme first enolizes the substrate to form the
intermediate 2-hydroxy-5-(methylthio)-3-oxopent-1-enyl phosphate,
which is then dephosphorylated to form the acireductone 1,2-
dihydroxy-5-(methylthio)pent-1-en-3-one.
- The acireductone represents a branch point in the methione salvage
pathway as it is used in the formation of formate, CO and
3-(methylthio)propanoate by EC 1.13.11.53 and of formate and
4-methylthio-2-oxobutanoate either by a spontaneous reaction under
aerobic conditions or by EC 1.13.11.54.
|
| Cross-references |
|---|
| BRENDA | 3.1.3.77 |
| PUMA2 | 3.1.3.77 |
| PRIAM enzyme-specific profiles | 3.1.3.77 |
| KEGG Ligand Database for Enzyme Nomenclature | 3.1.3.77 |
| IUBMB Enzyme Nomenclature | 3.1.3.77 |
| IntEnz | 3.1.3.77 |
| MEDLINE | Find literature relating to 3.1.3.77 |
| MetaCyc | 3.1.3.77 |
| UniProtKB/Swiss-Prot |
|
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