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ENZYME

ENZYME entry: EC 3.1.3.67

Accepted Name
phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase
Alternative Name(s)
phosphatidylinositol-3,4,5-trisphosphate 3-phosphohydrolase
Reaction catalysed
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate
Comment(s)
  • Does not dephosphorylate inositol 4,5-bisphosphate.
  • This enzyme still works when the 2,3-bis(acyloxy)propyl group is removed, i.e., it hydrolyzes Ins(1,3,4,5)P4 to Ins(1,4,5)P3.
Cross-references
BRENDA3.1.3.67
EC2PDB3.1.3.67
ExplorEnz3.1.3.67
PRIAM enzyme-specific profiles3.1.3.67
KEGG Ligand Database for Enzyme Nomenclature3.1.3.67
IUBMB Enzyme Nomenclature3.1.3.67
IntEnz3.1.3.67
MEDLINEFind literature relating to 3.1.3.67
MetaCyc3.1.3.67
Rhea expert-curated reactions3.1.3.67
UniProtKB/Swiss-Prot
Q54JL7, CNRN_DICDIQ9FLZ5, PTEN1_ARATHG5EE01, PTEN_CAEEL
P60483, PTEN_CANLFQ8T9S7, PTEN_DICDIP60484, PTEN_HUMAN
O08586, PTEN_MOUSEO54857, PTEN_RATO94526, PTEN_SCHPO
Q9PUT6, PTEN_XENLAQ9LT75, PTN2A_ARATHQ8H106, PTN2B_ARATH
P53916, TEP1_YEASTQ6XPS3, TPTE2_HUMANQ4R6N0, TPTE2_MACFA

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.1.3.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-