| Official Name |
|---|
| Phosphoinositide 5-phosphatase.
|
| Alternative Name(s) |
|---|
| Diphosphoinositide phosphatase. |
| Inositol 1,4,5-triphosphate 5-phosphomonoesterase. |
| Inositol triphosphate 5-phosphomonoesterase. |
| IP(3) phosphatase. |
| Phosphatidyl-inositol-bisphosphate phosphatase. |
| Phosphatidyl-myo-inositol-4,5-bisphosphate phosphatase. |
| Phosphatidylinositol 4,5-bisphosphate phosphatase. |
| Phosphatidylinositol-bisphosphatase. |
| Polyphosphoinositol lipid 5-phosphatase. |
| PtdIns(4,5)P(2) phosphatase. |
| Triphosphoinositide phosphatase. |
| Triphosphoinositide phosphomonoesterase. |
| Type II inositol polyphosphate 5-phosphatase. |
| Type II inositol-1,4,5-trisphosphate 5-phosphatase. |
| Reaction catalysed |
|---|
| 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O <=> 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate |
| Comment(s) |
|---|
- These enzymes can also remove the 5-phosphate from Ins(1,4,5)P(3)
and/or Ins(1,3,4,5)P(4).
- They are a diverse family of enzymes, with differing abilities to
catalyze two or more of the four reactions listed.
- They are thought to use inositol lipids rather than inositol
phosphates as substrates in vivo.
- All of them can use either or both of PtdIns(4,5)P(2) and
PtdIns(3,4,5)P(3) as substrates; this is the main property that
distinguishes them from EC 3.1.3.56.
|
| Cross-references |
|---|
| BRENDA | 3.1.3.36 |
| PUMA2 | 3.1.3.36 |
| PRIAM enzyme-specific profiles | 3.1.3.36 |
| KEGG Ligand Database for Enzyme Nomenclature | 3.1.3.36 |
| IUBMB Enzyme Nomenclature | 3.1.3.36 |
| IntEnz | 3.1.3.36 |
| MEDLINE | Find literature relating to 3.1.3.36 |
| MetaCyc | 3.1.3.36 |
| UniProtKB/Swiss-Prot |
| P32019, I5P2_HUMAN; | Q12271, INP53_YEAST; | Q08227, INP54_YEAST; |
| Q9NRR6, INP5E_HUMAN; | Q9JII1, INP5E_MOUSE; | A0FI79, INP5E_PANTR; |
| Q9WVR1, INP5E_RAT; | Q84W55, IP5PC_ARATH; | Q01968, OCRL_HUMAN; |
| O43001, SYJ1_SCHPO; | O18964, SYNJ1_BOVIN; | O43426, SYNJ1_HUMAN; |
| Q8CHC4, SYNJ1_MOUSE; | Q62910, SYNJ1_RAT; | O15056, SYNJ2_HUMAN; |
| Q9D2G5, SYNJ2_MOUSE; | O55207, SYNJ2_RAT; |
|
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