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NiceZyme View of ENZYME: EC 3.1.1.81

Accepted Name
Quorum-quenching N-acyl-homoserine lactonase.
Alternative Name(s)
Acyl homoserine degrading enzyme.
Acyl-homoserine-lactone acylase.
AHL lactonase.
AHL-degrading enzyme.
AHL-inactivating enzyme.
AHLase.
N-acyl homoserine lactonase.
N-acyl homoserine lactone hydrolase.
N-acyl-homoserine lactone lactonase.
N-acyl-L-homoserine lactone hydrolase.
Quorum-quenching lactonase.
Quorum-quenching N-acyl homoserine lactone hydrolase.
Reaction catalysed
An N-acyl-L-homoserine lactone + H(2)O <=> an N-acyl-L-homoserine
Comment(s)
  • Acyl-homoserine lactones (AHLs) are produced by a number of bacterial species and are used by them to regulate the expression of virulence genes in a process known as quorum-sensing.
  • Each bacterial cell has a basal level of AHL and, once the population density reaches a critical level, it triggers AHL-signaling which, in turn, initiates the expression of particular virulence genes.
  • Plants or animals capable of degrading AHLs would have a therapeutic advantage in avoiding bacterial infection as they could prevent AHL- signaling and the expression of virulence genes in quorum-sensing bacteria.
  • N-(3-oxohexanoyl)-L-homoserine lactone, N-(3-oxododecanoyl)-L- homoserine lactone, N-butanoyl-L-homoserine lactone and N-(3-oxooctanoyl)-L-homoserine lactone can act as substrates.
Cross-references
BRENDA3.1.1.81
EC2PDB3.1.1.81
PRIAM enzyme-specific profiles3.1.1.81
KEGG Ligand Database for Enzyme Nomenclature3.1.1.81
IUBMB Enzyme Nomenclature3.1.1.81
IntEnz3.1.1.81
MEDLINEFind literature relating to 3.1.1.81
MetaCyc3.1.1.81

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.1.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-