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NiceZyme View of ENZYME: EC 2.7.8.7

Accepted Name
Holo-[acyl-carrier-protein] synthase.
Alternative Name(s)
4'-phosphopantetheinyl transferase.
ACPS.
Acyl carrier protein holoprotein (holo-ACP) synthetase.
Acyl carrier protein synthase.
Acyl carrier protein synthetase.
Alpha-aminoadipic semialdehyde dehydrogenase-phosphopantetheinyl transferase.
Holo-ACP synthase.
Holo-ACP synthetase.
Holosynthase.
L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase.
P-pant transferase.
PPTase.
Reaction catalysed
CoA-(4'-phosphopantetheine) + apo-[acyl-carrier-protein] <=> adenosine 3',5'-bisphosphate + holo-[acyl-carrier-protein]
Cofactor(s)
Magnesium.
Comment(s)
  • All polyketide synthases, fatty-acid synthases and non-ribosomal peptide synthases require post-translational modification of their constituent acyl-carrier-protein (ACP) domains to become catalytically active.
  • The inactive apo-proteins are converted into their active holo-forms by transfer of the 4'-phosphopantetheinyl moiety of CoA to the sidechain hydroxy group of a conserved serine residue in each ACP domain.
  • The enzyme from human can activate both the ACP domain of the human cytosolic multifunctional fatty acid synthase and that associated with human mitochondria as well as peptidyl-carrier and acyl-carrier- proteins from prokaryotes.
  • Removal of the 4-phosphopantetheinyl moiety from holo-ACP is carried out by EC 3.1.4.14.
Cross-references
Biochemical Pathways; map number(s)F8
BRENDA2.7.8.7
EC2PDB2.7.8.7
PRIAM enzyme-specific profiles2.7.8.7
KEGG Ligand Database for Enzyme Nomenclature2.7.8.7
IUBMB Enzyme Nomenclature2.7.8.7
IntEnz2.7.8.7
MEDLINEFind literature relating to 2.7.8.7
MetaCyc2.7.8.7
UniProtKB/Swiss-Prot
Q8XAN7, ACPS2_ECO57;  A9NHV3, ACPS_ACHLI;  Q1IHY2, ACPS_ACIBL;  
A5FVX4, ACPS_ACICJ;  B7J9K5, ACPS_ACIF2;  B5EQL7, ACPS_ACIF5;  
A1WAW0, ACPS_ACISJ;  Q8UGK4, ACPS_AGRT5;  Q0A8Y7, ACPS_ALHEH;  
B6EKM5, ACPS_ALISL;  A6TVL0, ACPS_ALKMQ;  A8MJ27, ACPS_ALKOO;  
B4RXM9, ACPS_ALTMD;  Q2IHZ3, ACPS_ANADE;  A7HCT8, ACPS_ANADF;  
Q5PAZ6, ACPS_ANAMM;  Q2GK71, ACPS_ANAPZ;  B4UEM2, ACPS_ANASK;  
B7GIY1, ACPS_ANOFW;  O66995, ACPS_AQUAE;  A8ERC0, ACPS_ARCB4;  
A1R8P6, ACPS_ARTAT;  A0JZ20, ACPS_ARTS2;  A8I3B0, ACPS_AZOC5;  
A1K608, ACPS_AZOSB;  Q5P082, ACPS_AZOSE;  A7Z1L9, ACPS_BACA2;  
A0R8U9, ACPS_BACAH;  Q81JG3, ACPS_BACAN;  B7JLE6, ACPS_BACC0;  
Q73ET8, ACPS_BACC1;  B7IU30, ACPS_BACC2;  B7H4P0, ACPS_BACC4;  
B7HRY9, ACPS_BACC7;  A7GKE4, ACPS_BACCN;  Q81IT7, ACPS_BACCR;  
Q63GX2, ACPS_BACCZ;  Q9KFG1, ACPS_BACHD;  Q6HPE3, ACPS_BACHK;  
A8FA63, ACPS_BACP2;  Q5WJW1, ACPS_BACSK;  P96618, ACPS_BACSU;  
A9VQF0, ACPS_BACWK;  A1US34, ACPS_BARBK;  Q6G461, ACPS_BARHE;  
Q6G084, ACPS_BARQU;  A9IRM3, ACPS_BART1;  Q1LTI6, ACPS_BAUCH;  
B2II98, ACPS_BEII9;  A1A005, ACPS_BIFAA;  Q7VRR2, ACPS_BLOFL;  
Q492D3, ACPS_BLOPB;  Q0SPF4, ACPS_BORAP;  Q7WH64, ACPS_BORBR;  
O51043, ACPS_BORBU;  B7J0U9, ACPS_BORBZ;  Q663A2, ACPS_BORGA;  
B2S1J9, ACPS_BORHD;  Q7W9J6, ACPS_BORPA;  Q7VWV9, ACPS_BORPE;  
O69159, ACPS_BRAJA;  A5EKL9, ACPS_BRASB;  B2SAD7, ACPS_BRUA1;  
Q2YN04, ACPS_BRUA2;  Q57E83, ACPS_BRUAB;  A9MA33, ACPS_BRUC2;  
P63464, ACPS_BRUME;  A5VPJ6, ACPS_BRUO2;  B0CKY5, ACPS_BRUSI;  
P63465, ACPS_BRUSU;  P57344, ACPS_BUCAI;  Q8K9R3, ACPS_BUCAP;  
P59475, ACPS_BUCBP;  Q057R6, ACPS_BUCCC;  B1YVM8, ACPS_BURA4;  
Q1BXT7, ACPS_BURCA;  B1JYB7, ACPS_BURCC;  A0K5W3, ACPS_BURCH;  
Q0BH00, ACPS_BURCM;  A9ADD4, ACPS_BURM1;  A3MM38, ACPS_BURM7;  
A2S9Z9, ACPS_BURM9;  Q62LS6, ACPS_BURMA;  A1V6B3, ACPS_BURMS;  
A3NXL2, ACPS_BURP0;  A3NBS5, ACPS_BURP6;  B2JFK6, ACPS_BURP8;  
B2SZV1, ACPS_BURPP;  Q63S99, ACPS_BURPS;  Q39I69, ACPS_BURS3;  
Q2SXT0, ACPS_BURTA;  A4JCR5, ACPS_BURVG;  A4XIB7, ACPS_CALS8;  
A7ZDS5, ACPS_CAMC1;  A7GY16, ACPS_CAMC5;  A0RPF9, ACPS_CAMFF;  
A7I379, ACPS_CAMHC;  A8FN84, ACPS_CAMJ8;  A7H5D0, ACPS_CAMJD;  
Q9PMP8, ACPS_CAMJE;  A1W123, ACPS_CAMJJ;  Q5HT08, ACPS_CAMJR;  
Q3AEB5, ACPS_CARHZ;  Q9A807, ACPS_CAUCR;  B0T3H7, ACPS_CAUSK;  
A9WE63, ACPS_CHLAA;  Q5L623, ACPS_CHLAB;  Q3AU14, ACPS_CHLCH;  
Q820E7, ACPS_CHLCV;  Q254H8, ACPS_CHLFF;  B3EGP9, ACPS_CHLL2;  
Q9PKT6, ACPS_CHLMU;  B3QR46, ACPS_CHLP8;  Q9Z8M5, ACPS_CHLPN;  
B0B9K8, ACPS_CHLT2;  B3QTH9, ACPS_CHLT3;  Q3KMS0, ACPS_CHLTA;  
B0BB87, ACPS_CHLTB;  Q8KB56, ACPS_CHLTE;  O84102, ACPS_CHLTR;  
Q7NWB8, ACPS_CHRVO;  A8AD21, ACPS_CITK8;  A5CU72, ACPS_CLAM3;  
B0RD39, ACPS_CLAMS;  Q97LR5, ACPS_CLOAB;  A6M302, ACPS_CLOB8;  
B2V003, ACPS_CLOBA;  B2TQY6, ACPS_CLOBB;  A5N379, ACPS_CLOK5;  
A0PY92, ACPS_CLONN;  Q0TUE3, ACPS_CLOP1;  Q8XNP1, ACPS_CLOPE;  
A9KLF9, ACPS_CLOPH;  Q0SW89, ACPS_CLOPS;  Q890W8, ACPS_CLOTE;  
B5Y8E2, ACPS_COPPD;  Q8FMW0, ACPS_COREF;  A4QGP6, ACPS_CORGB;  
Q8NMS4, ACPS_CORGL;  B3R1Z5, ACPS_CUPTR;  Q11T75, ACPS_CYTH3;  
Q47EF3, ACPS_DECAR;  Q3Z9B0, ACPS_DEHE1;  A5FS12, ACPS_DEHSB;  
Q3ZZK3, ACPS_DEHSC;  Q9RXR0, ACPS_DEIRA;  A9BNJ1, ACPS_DELAS;  
B1I1U5, ACPS_DESAP;  Q30ZQ5, ACPS_DESDG;  A4J8G9, ACPS_DESRM;  
Q72AT2, ACPS_DESVH;  B8DPF0, ACPS_DESVM;  A1VCV8, ACPS_DESVV;  
A8LLD7, ACPS_DINSH;  A7ZQ07, ACPS_ECO24;  B7MIP8, ACPS_ECO45;  
Q8XA39, ACPS_ECO57;  B7NRL6, ACPS_ECO7I;  B7M8H6, ACPS_ECO8A;  
A8A373, ACPS_ECOHS;  A1AE93, ACPS_ECOK1;  Q0TES5, ACPS_ECOL5;  
Q8FF19, ACPS_ECOL6;  B1IVR4, ACPS_ECOLC;  P24224, ACPS_ECOLI;  
B7N6F1, ACPS_ECOLU;  B6I5D7, ACPS_ECOSE;  B1LP76, ACPS_ECOSM;  
Q1R8H0, ACPS_ECOUT;  Q3YSD5, ACPS_EHRCJ;  Q2GG91, ACPS_EHRCR;  
Q5FHL6, ACPS_EHRRG;  Q5HBI7, ACPS_EHRRW;  A4WDD4, ACPS_ENT38;  
Q820V0, ACPS_ENTFA;  A7MH03, ACPS_ENTS8;  Q6D222, ACPS_ERWCT;  
B2VEA7, ACPS_ERWT9;  Q2NCF7, ACPS_ERYLH;  B7LV01, ACPS_ESCF3;  
B1YF32, ACPS_EXIS2;  B0S2M4, ACPS_FINM2;  Q0RRN3, ACPS_FRAAA;  
Q2JFD8, ACPS_FRASC;  Q8RDZ7, ACPS_FUSNN;  B5EI15, ACPS_GEOBB;  
Q5L3G7, ACPS_GEOKA;  B3E694, ACPS_GEOLS;  Q39UG1, ACPS_GEOMG;  
Q74C71, ACPS_GEOSL;  A4IJT3, ACPS_GEOTN;  Q7NE72, ACPS_GLOVI;  
Q5FPZ9, ACPS_GLUOX;  Q0BTG4, ACPS_GRABC;  A1WT13, ACPS_HALHL;  
Q17XL2, ACPS_HELAH;  B6JM38, ACPS_HELP2;  B5Z7H0, ACPS_HELPG;  
Q1CT62, ACPS_HELPH;  Q9ZL36, ACPS_HELPJ;  O25488, ACPS_HELPY;  
A9B2B6, ACPS_HERA2;  A4G6R4, ACPS_HERAR;  B4U7U7, ACPS_HYDS0;  
Q0C3U0, ACPS_HYPNA;  Q5R110, ACPS_IDILO;  A6SXR7, ACPS_JANMA;  
Q28V25, ACPS_JANSC;  A6W5X5, ACPS_KINRD;  B5XNH4, ACPS_KLEP3;  
A6TCH7, ACPS_KLEP7;  B2GJ30, ACPS_KOCRD;  Q5FMB3, ACPS_LACAC;  
Q03T07, ACPS_LACBA;  Q034T8, ACPS_LACC3;  B3WAR1, ACPS_LACCB;  
Q1GBP7, ACPS_LACDA;  Q04C46, ACPS_LACDB;  B2GA64, ACPS_LACF3;  
A8YXI2, ACPS_LACH4;  Q74LB3, ACPS_LACJO;  Q9CH95, ACPS_LACLA;  
A2RLV5, ACPS_LACLM;  Q030B5, ACPS_LACLS;  Q88Z44, ACPS_LACPL;  
A5VI50, ACPS_LACRD;  Q9FCV3, ACPS_LACRE;  B2G5M8, ACPS_LACRJ;  
Q1WV15, ACPS_LACS1;  Q38V63, ACPS_LACSS;  Q6AD33, ACPS_LEIXX;  
B0SE17, ACPS_LEPBA;  Q04U76, ACPS_LEPBJ;  Q053N9, ACPS_LEPBL;  
B0SM94, ACPS_LEPBP;  B1XZM3, ACPS_LEPCP;  Q72U18, ACPS_LEPIC;  
Q8F136, ACPS_LEPIN;  B1MX05, ACPS_LEUCK;  Q03V72, ACPS_LEUMM;  
Q92DD0, ACPS_LISIN;  Q721T0, ACPS_LISMF;  Q8Y8L2, ACPS_LISMO;  
A0AH03, ACPS_LISW6;  Q2W515, ACPS_MAGMM;  A0L8S4, ACPS_MAGSM;  
Q0APC3, ACPS_MARMM;  A6VUP9, ACPS_MARMS;  Q11JT0, ACPS_MESSB;  
A9W511, ACPS_METEP;  B1Z872, ACPS_METPB;  A2SDH7, ACPS_METPP;  
B1LTR5, ACPS_METRJ;  B0UE20, ACPS_METS4;  Q2RGI1, ACPS_MOOTA;  
P0A4W9, ACPS_MYCBO;  A1KLL9, ACPS_MYCBP;  Q2SS83, ACPS_MYCCT;  
Q7NB74, ACPS_MYCGA;  Q9ZB79, ACPS_MYCGE;  Q9X7E3, ACPS_MYCLE;  
B2HPL7, ACPS_MYCMM;  Q6KHG5, ACPS_MYCMO;  Q6MT35, ACPS_MYCMS;  
Q73XH8, ACPS_MYCPA;  P75480, ACPS_MYCPN;  Q98R97, ACPS_MYCPU;  
A0R1H6, ACPS_MYCS2;  A3Q2R0, ACPS_MYCSJ;  A1UJA6, ACPS_MYCSK;  
Q1B5T0, ACPS_MYCSS;  A5U5M1, ACPS_MYCTA;  P0A4W8, ACPS_MYCTU;  
A0PU93, ACPS_MYCUA;  Q1D4A0, ACPS_MYXXD;  B2A4X6, ACPS_NATTJ;  
Q5F6P2, ACPS_NEIG1;  B4RQ92, ACPS_NEIG2;  A9M273, ACPS_NEIM0;  
Q9RQW2, ACPS_NEIMA;  P0A0Q5, ACPS_NEIMB;  P0A0Q6, ACPS_NEIMC;  
A1KVH5, ACPS_NEIMF;  Q0AF73, ACPS_NITEC;  Q820I1, ACPS_NITEU;  
Q1QL52, ACPS_NITHX;  Q2Y864, ACPS_NITMU;  Q3JCY7, ACPS_NITOC;  
A6Q3W1, ACPS_NITSB;  Q3SRB1, ACPS_NITWN;  Q5Z0D8, ACPS_NOCFA;  
A1SF35, ACPS_NOCSJ;  Q8ESK9, ACPS_OCEIH;  Q04DI0, ACPS_OENOB;  
B6JGF9, ACPS_OLICO;  Q6YQD4, ACPS_ONYPE;  A5CDM0, ACPS_ORITB;  
B3CQ27, ACPS_ORITI;  A1AZ41, ACPS_PARDP;  A7HX46, ACPS_PARL1;  
Q6MAG4, ACPS_PARUW;  Q03DZ1, ACPS_PEDPA;  Q3A5V3, ACPS_PELCD;  
Q3B672, ACPS_PELLD;  B4SFE8, ACPS_PELPB;  A1AR95, ACPS_PELPD;  
Q4FLS7, ACPS_PELUB;  A9BJX6, ACPS_PETMO;  B4RCU9, ACPS_PHEZH;  
Q7N1X9, ACPS_PHOLL;  Q6LMS5, ACPS_PHOPR;  A1VRS8, ACPS_POLNA;  
B1XTL7, ACPS_POLNS;  Q126K7, ACPS_POLSJ;  A4SVW6, ACPS_POLSQ;  
Q6A6U0, ACPS_PROAC;  A4SCZ9, ACPS_PROVI;  Q15PH8, ACPS_PSEA6;  
Q0K8N7, ACPS_RALEH;  Q46Z22, ACPS_RALEJ;  Q1LKN5, ACPS_RALME;  
Q8Y0H7, ACPS_RALSO;  A9WMF1, ACPS_RENSM;  B3PUN6, ACPS_RHIE6;  
Q2KAE5, ACPS_RHIEC;  Q1MJ56, ACPS_RHIL3;  Q985A8, ACPS_RHILO;  
B5ZW71, ACPS_RHILW;  Q92R49, ACPS_RHIME;  Q7UQA5, ACPS_RHOBA;  
B6IN03, ACPS_RHOCS;  Q21XM1, ACPS_RHOFD;  Q2IWU7, ACPS_RHOP2;  
Q07M73, ACPS_RHOP5;  Q6N6C3, ACPS_RHOPA;  Q214J8, ACPS_RHOPB;  
Q136W1, ACPS_RHOPS;  B3QJH2, ACPS_RHOPT;  A3PGF6, ACPS_RHOS1;  
Q3J5W3, ACPS_RHOS4;  A4WVP7, ACPS_RHOS5;  A8GP44, ACPS_RICAH;  
A8GW65, ACPS_RICB8;  Q1RHU1, ACPS_RICBR;  A8EYA8, ACPS_RICCK;  
Q92H90, ACPS_RICCN;  Q4UKX9, ACPS_RICFE;  A8F257, ACPS_RICM5;  
Q9ZCX5, ACPS_RICPR;  B0BYC4, ACPS_RICRO;  A8GSU8, ACPS_RICRS;  
Q68WF9, ACPS_RICTY;  A7NPN5, ACPS_ROSCS;  Q16AI8, ACPS_ROSDO;  
A1AWQ3, ACPS_RUTMC;  A4FPF7, ACPS_SACEN;  B5F1F7, ACPS_SALA4;  
A8M4B5, ACPS_SALAI;  A9MGY0, ACPS_SALAR;  Q57LD4, ACPS_SALCH;  
B5FRC1, ACPS_SALDC;  B5QTU4, ACPS_SALEP;  B5RD45, ACPS_SALG2;  
B4TE11, ACPS_SALHS;  B4T1F4, ACPS_SALNS;  Q5PIJ4, ACPS_SALPA;  
A9N1T5, ACPS_SALPB;  B5BAT4, ACPS_SALPK;  B4TS10, ACPS_SALSV;  
P63467, ACPS_SALTI;  A4XBI2, ACPS_SALTO;  P63466, ACPS_SALTY;  
A8GI21, ACPS_SERP5;  A1S3Y5, ACPS_SHEAM;  A3D1W0, ACPS_SHEB5;  
A6WKR1, ACPS_SHEB8;  A9L5P0, ACPS_SHEB9;  Q12KI5, ACPS_SHEDO;  
Q07Z00, ACPS_SHEFN;  B0TIW1, ACPS_SHEHH;  A3QBT1, ACPS_SHELP;  
Q8EH77, ACPS_SHEON;  A8H1D1, ACPS_SHEPA;  A4Y4K8, ACPS_SHEPC;  
B8CQJ1, ACPS_SHEPW;  A0KZM8, ACPS_SHESA;  A8FSE0, ACPS_SHESH;  
Q0HGA2, ACPS_SHESM;  Q0HSJ5, ACPS_SHESR;  A1RMC3, ACPS_SHESW;  
B1KI61, ACPS_SHEWM;  B2TXX6, ACPS_SHIB3;  Q31XS4, ACPS_SHIBS;  
Q32CV8, ACPS_SHIDS;  Q0T1U2, ACPS_SHIF8;  Q83K24, ACPS_SHIFL;  
Q3YYV3, ACPS_SHISS;  Q5LNK3, ACPS_SILPO;  Q1GDH3, ACPS_SILST;  
A6U7A6, ACPS_SINMW;  Q2NS17, ACPS_SODGM;  Q01RT7, ACPS_SOLUE;  
Q1GT99, ACPS_SPHAL;  A5VD51, ACPS_SPHWW;  A7X4P8, ACPS_STAA1;  
A6U3F7, ACPS_STAA2;  Q2FF54, ACPS_STAA3;  Q9ZAH6, ACPS_STAA8;  
A5IUL7, ACPS_STAA9;  Q2YUI2, ACPS_STAAB;  Q5HED0, ACPS_STAAC;  
A6QIR6, ACPS_STAAE;  P63468, ACPS_STAAM;  P63469, ACPS_STAAN;  
Q6GF02, ACPS_STAAR;  Q6G7N8, ACPS_STAAS;  A8Z4X4, ACPS_STAAT;  
P63470, ACPS_STAAW;  Q5HME4, ACPS_STAEQ;  Q8CNK6, ACPS_STAES;  
Q4L7V6, ACPS_STAHJ;  Q49Z25, ACPS_STAS1;  Q3JZK4, ACPS_STRA1;  
P63471, ACPS_STRA3;  P63472, ACPS_STRA5;  Q82DL2, ACPS_STRAW;  
O86785, ACPS_STRCO;  B4U177, ACPS_STREM;  B1W3W2, ACPS_STRGG;  
Q8DSF3, ACPS_STRMU;  Q99Y97, ACPS_STRP1;  Q04J73, ACPS_STRP2;  
P63473, ACPS_STRP3;  B5E746, ACPS_STRP4;  Q5XAA3, ACPS_STRP6;  
P63474, ACPS_STRP8;  Q1JA49, ACPS_STRPB;  Q1JK99, ACPS_STRPC;  
Q1JF93, ACPS_STRPD;  Q1J544, ACPS_STRPF;  A2RCT2, ACPS_STRPG;  
B1I756, ACPS_STRPI;  Q48RM7, ACPS_STRPM;  P0A2W6, ACPS_STRPN;  
B5XI22, ACPS_STRPZ;  P0A2W7, ACPS_STRR6;  A4W3N6, ACPS_STRS2;  
A3CLD6, ACPS_STRSV;  A4VXE0, ACPS_STRSY;  Q5LY70, ACPS_STRT1;  
Q5M2S6, ACPS_STRT2;  Q03IX7, ACPS_STRTD;  Q30SB4, ACPS_SULDN;  
A6Q7U5, ACPS_SULNB;  Q67K77, ACPS_SYMTH;  Q2LTJ7, ACPS_SYNAS;  
Q9WZF6, ACPS_THEMA;  B0KD52, ACPS_THEP3;  B0K5Y6, ACPS_THEPX;  
Q72IV9, ACPS_THET2;  Q5SII1, ACPS_THET8;  Q8R857, ACPS_THETN;  
B5YJG8, ACPS_THEYD;  Q31HN9, ACPS_THICR;  Q3SKU1, ACPS_THIDA;  
Q73LF7, ACPS_TREDE;  O83800, ACPS_TREPA;  B2S466, ACPS_TREPS;  
B1AJ32, ACPS_UREP2;  Q9PQ97, ACPS_UREPA;  A1WKY6, ACPS_VEREI;  
A5CWJ8, ACPS_VESOH;  A5F5H4, ACPS_VIBC3;  Q9KPB6, ACPS_VIBCH;  
Q5E318, ACPS_VIBF1;  B5FAG6, ACPS_VIBFM;  A7MZA4, ACPS_VIBHB;  
Q87LP3, ACPS_VIBPA;  Q8DC72, ACPS_VIBVU;  Q7MHP2, ACPS_VIBVY;  
Q8D303, ACPS_WIGBR;  Q73GW5, ACPS_WOLPM;  B3CL63, ACPS_WOLPP;  
Q7M803, ACPS_WOLSU;  Q5GTK4, ACPS_WOLTR;  A7IM60, ACPS_XANP2;  
A1JKK7, ACPS_YERE8;  A7FFU3, ACPS_YERP3;  Q1C5D9, ACPS_YERPA;  
B2KA43, ACPS_YERPB;  Q8ZCP5, ACPS_YERPE;  A9R406, ACPS_YERPG;  
Q1CKE0, ACPS_YERPN;  A4TKX4, ACPS_YERPP;  Q667V4, ACPS_YERPS;  
B1JRD1, ACPS_YERPY;  Q5NLS7, ACPS_ZYMMO;  Q75BZ1, PPT2_ASHGO;  
Q6FJZ5, PPT2_CANGA;  Q12036, PPT2_YEAST;  

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