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NiceZyme View of ENZYME: EC 2.7.7.63

Official Name
Lipoate--protein ligase.
Alternative Name(s)
Lipoate protein ligase.
Lipoate-protein ligase A.
LPL.
Reaction catalysed
  • ATP + lipoate <=> diphosphate + lipoyl-AMP
  • Lipoyl-AMP + protein <=> protein N(6)-(lipoyl)lysine + AMP
Cofactor(s)
Magnesium.
Comment(s)
  • Both 6S- and 6R-lipoates can act as substrates but there is a preference for the naturally occurring R-form.
  • Selenolipoate, i.e. 5-(1,2-diselenolan-3-yl)pentanoic acid, and 6-sulfanyloctanoate can also act as substrates, but more slowly.
  • Responsible for lipoylation in the presence of exogenous lipoic acid.
  • Lipoylation is essential for the function of several key enzymes involved in oxidative metabolism, including pyruvate dehydrogenase (E(2) domain), 2-oxoglutarate dehydrogenase (E(2) domain), the branched-chain 2-oxoacid dehydrogenases and the glycine cleavage system (H protein).
  • Attaches lipoic acid to the lipoyl domains of these proteins.
  • It is likely that an alternative pathway, involving EC 2.3.1.181 and EC 2.8.1.8 is the normal route for lipoylation.
Cross-references
BRENDA2.7.7.63
PUMA22.7.7.63
PRIAM enzyme-specific profiles2.7.7.63
KEGG Ligand Database for Enzyme Nomenclature2.7.7.63
IUBMB Enzyme Nomenclature2.7.7.63
IntEnz2.7.7.63
MEDLINEFind literature relating to 2.7.7.63
MetaCyc2.7.7.63
UniProtKB/Swiss-Prot
A0KMH0, LPLA_AERHH;  Q9Y9E6, LPLA_AERPE;  A4SQ09, LPLA_AERS4;  
P60809, LPLA_BDEBA;  Q7VR65, LPLA_BLOFL;  Q492U9, LPLA_BLOPB;  
A8ALX2, LPLA_CITK8;  A7ZVS8, LPLA_ECO24;  P60776, LPLA_ECO57;  
A8A8B4, LPLA_ECOHS;  A1AJV3, LPLA_ECOK1;  Q0T8S7, LPLA_ECOL5;  
Q8FA49, LPLA_ECOL6;  B1IS33, LPLA_ECOLC;  P32099, LPLA_ECOLI;  
Q1R257, LPLA_ECOUT;  A4W6A2, LPLA_ENT38;  A7MIG6, LPLA_ENTS8;  
A6TI00, LPLA_KLEP7;  P47512, LPLA_MYCGE;  P75394, LPLA_MYCPN;  
Q1QEC2, LPLA_PSYCK;  A9MRA3, LPLA_SALAR;  Q57G36, LPLA_SALCH;  
Q5PK29, LPLA_SALPA;  A9N7E6, LPLA_SALPB;  Q8Z0U0, LPLA_SALTI;  
Q8ZJV1, LPLA_SALTY;  O13629, LPLA_SCHPO;  A8GDS3, LPLA_SERP5;  
Q31SV2, LPLA_SHIBS;  Q327K9, LPLA_SHIDS;  Q3YU08, LPLA_SHISS;  
Q9HKT1, LPLA_THEAC;  A5F8E4, LPLA_VIBC3;  Q9KS71, LPLA_VIBCH;  
P47051, LPLA_YEAST;  A1JPK8, LPLA_YERE8;  A7FHI0, LPLA_YERP3;  
Q1C748, LPLA_YERPA;  Q8ZDY2, LPLA_YERPE;  Q1CII3, LPLA_YERPN;  
A4TIN0, LPLA_YERPP;  Q66A10, LPLA_YERPS;  

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