ID   2.7.11.12
DE   cGMP-dependent protein kinase.
AN   3':5'-cyclic GMP-dependent protein kinase.
AN   cGMP-dependent protein kinase I-beta.
AN   Guanosine 3':5'-cyclic monophosphate-dependent protein kinase.
AN   PKG.
AN   PKG 1-alpha.
AN   PKG 1-beta.
AN   PKG II.
CA   ATP + a protein = ADP + a phosphoprotein.
CC   -!- cGMP is required to activate this enzyme.
CC   -!- The enzyme occurs as a dimer in higher eukaryotes.
CC   -!- The C-terminal region of each polypeptide chain contains the
CC       catalytic domain that includes the ATP and protein substrate binding
CC       sites.
CC   -!- This domain catalyzes the phosphorylation by ATP to specific serine
CC       or threonine residues in protein substrates.
CC   -!- The enzyme also has two allosteric cGMP-binding sites (sites A and
CC       B).
CC   -!- Binding of cGMP causes a conformational change that is associated
CC       with activation of the kinase.
PR   PROSITE; PDOC00100;
DR   A8X6H1, EGL4_CAEBR ;  O76360, EGL4_CAEEL ;  P00516, KGP1_BOVIN ;
DR   Q03042, KGP1_DROME ;  Q13976, KGP1_HUMAN ;  P0C605, KGP1_MOUSE ;
DR   O77676, KGP1_RABIT ;  Q03043, KGP24_DROME;  P32023, KGP25_DROME;
DR   Q13237, KGP2_HUMAN ;  Q61410, KGP2_MOUSE ;  Q64595, KGP2_RAT   ;
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