| Accepted Name |
|---|
| cGMP-dependent protein kinase.
|
| Alternative Name(s) |
|---|
| 3':5'-cyclic GMP-dependent protein kinase. |
| cGMP-dependent protein kinase I-beta. |
| Guanosine 3':5'-cyclic monophosphate-dependent protein kinase. |
| PKG. |
| PKG 1-alpha. |
| PKG 1-beta. |
| PKG II. |
| Reaction catalysed |
|---|
| ATP + a protein <=> ADP + a phosphoprotein |
| Comment(s) |
|---|
- cGMP is required to activate this enzyme.
- The enzyme occurs as a dimer in higher eukaryotes.
- The C-terminal region of each polypeptide chain contains the
catalytic domain that includes the ATP and protein substrate binding
sites.
- This domain catalyzes the phosphorylation by ATP to specific serine
or threonine residues in protein substrates.
- The enzyme also has two allosteric cGMP-binding sites (sites A and
B).
- Binding of cGMP causes a conformational change that is associated
with activation of the kinase.
|
| Cross-references |
|---|
| PROSITE | PDOC00100 |
| BRENDA | 2.7.11.12 |
| EC2PDB | 2.7.11.12 |
| PRIAM enzyme-specific profiles | 2.7.11.12 |
| KEGG Ligand Database for Enzyme Nomenclature | 2.7.11.12 |
| IUBMB Enzyme Nomenclature | 2.7.11.12 |
| IntEnz | 2.7.11.12 |
| MEDLINE | Find literature relating to 2.7.11.12 |
| MetaCyc | 2.7.11.12 |
| UniProtKB/Swiss-Prot |
| P00516, KGP1A_BOVIN; | Q13976, KGP1A_HUMAN; | P0C605, KGP1A_MOUSE; |
| O77676, KGP1A_RABIT; | P21136, KGP1B_BOVIN; | P14619, KGP1B_HUMAN; |
| Q9Z0Z0, KGP1B_MOUSE; | Q03042, KGP1_DROME; | Q03043, KGP24_DROME; |
| P32023, KGP25_DROME; | Q13237, KGP2_HUMAN; | Q61410, KGP2_MOUSE; |
| Q64595, KGP2_RAT; |
|
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