| Accepted Name |
|---|
| Protein geranylgeranyltransferase type II.
|
| Alternative Name(s) |
|---|
| GGTaseII. |
| Rab geranylgeranyltransferase. |
| RabGGTase. |
| Type II protein geranyl-geranyltransferase. |
| Reaction catalysed |
|---|
| Geranylgeranyl diphosphate + protein-cysteine <=> S-geranylgeranyl-protein + diphosphate |
| Comment(s) |
|---|
- This enzyme, along with EC 2.5.1.58 and EC 2.5.1.59, constitutes the
protein prenyltransferase family of enzymes.
- Attaches geranylgeranyl groups to two C-terminal cysteines in Ras-
related GTPases of a single family, the Rab family (Ypt/Sec4 in lower
eukaryotes) that terminate in XXCC, XCXC and CCXX motifs.
- Reaction is entirely dependent on the Rab substrate being bound to
Rab escort protein (REP).
- Post-translational modification with the geranylgeranyl moiety is
essential for Rab GTPases to be able to control the processes of
membrane docking and fusion.
|
| Cross-references |
|---|
| PROSITE | PDOC00703 |
| BRENDA | 2.5.1.60 |
| EC2PDB | 2.5.1.60 |
| PRIAM enzyme-specific profiles | 2.5.1.60 |
| KEGG Ligand Database for Enzyme Nomenclature | 2.5.1.60 |
| IUBMB Enzyme Nomenclature | 2.5.1.60 |
| IntEnz | 2.5.1.60 |
| MEDLINE | Find literature relating to 2.5.1.60 |
| MetaCyc | 2.5.1.60 |
| UniProtKB/Swiss-Prot |
| Q5EA80, PGTA_BOVIN; | O93829, PGTA_CANAL; | Q55DQ4, PGTA_DICDI; |
| Q92696, PGTA_HUMAN; | Q9JHK4, PGTA_MOUSE; | A5A779, PGTA_PIG; |
| Q5NVK5, PGTA_PONAB; | Q08602, PGTA_RAT; | O94412, PGTA_SCHPO; |
| Q00618, PGTA_YEAST; | Q5E9B3, PGTB2_BOVIN; | P41992, PGTB2_CAEEL; |
| O93830, PGTB2_CANAL; | B0G172, PGTB2_DICDI; | P53611, PGTB2_HUMAN; |
| P53612, PGTB2_MOUSE; | Q08603, PGTB2_RAT; | P46960, PGTB2_SCHPO; |
| P20133, PGTB2_YEAST; |
|
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