| Accepted Name |
|---|
| Squalene synthase.
|
| Alternative Name(s) |
|---|
| Farnesyl-diphosphate farnesyltransferase. |
| Farnesyltransferase. |
| Presqualene synthase. |
| Presqualene-diphosphate synthase. |
| Squalene synthetase. |
| Reaction catalysed |
|---|
- 2 farnesyl diphosphate <=> diphosphate + presqualene diphosphate
- Presqualene diphosphate + NAD(P)H <=> squalene + diphosphate + NAD(P)(+)
|
| Cofactor(s) |
|---|
| Magnesium or manganese.
|
| Comment(s) |
|---|
- This microsomal enzyme catalyzes the first committed step in the
biosynthesis of sterols.
- In the absence of NAD(P)H, presqualene diphosphate (PSPP) is
accumulated.
- When NAD(P)H is present, presqualene diphosphate does not dissociate
from the enzyme during the synthesis of squalene from farnesyl
diphosphate (FPP).
- High concentrations of FPP inhibit the production of squalene but not
of PSPP.
|
| Cross-references |
|---|
| Biochemical Pathways; map number(s) | E10 |
| PROSITE | PDOC00802 |
| BRENDA | 2.5.1.21 |
| EC2PDB | 2.5.1.21 |
| PRIAM enzyme-specific profiles | 2.5.1.21 |
| KEGG Ligand Database for Enzyme Nomenclature | 2.5.1.21 |
| IUBMB Enzyme Nomenclature | 2.5.1.21 |
| IntEnz | 2.5.1.21 |
| MEDLINE | Find literature relating to 2.5.1.21 |
| MetaCyc | 2.5.1.21 |
| UniProtKB/Swiss-Prot |
| P53799, FDFT_ARATH; | Q752X9, FDFT_ASHGO; | Q32KR6, FDFT_BOVIN; |
| P78589, FDFT_CANAL; | Q9HGZ6, FDFT_CANGA; | Q54DR1, FDFT_DICDI; |
| P37268, FDFT_HUMAN; | P53798, FDFT_MOUSE; | Q7S4Z6, FDFT_NEUCR; |
| P53800, FDFT_NICBE; | O74165, FDFT_PICJA; | Q5R6U3, FDFT_PONAB; |
| Q02769, FDFT_RAT; | P36596, FDFT_SCHPO; | Q92459, FDFT_USTMA; |
| Q9Y753, FDFT_YARLI; | P29704, FDFT_YEAST; |
|
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