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ENZYME

ENZYME entry: EC 2.5.1.114

Accepted Name
tRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase
Alternative Name(s)
tRNA-yW synthesizing enzyme-2
Reaction catalysed
4-demethylwyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine <=> 4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + H(+) + S-methyl-5'-thioadenosine
Comment(s)
  • The enzyme, which is found in all eukaryotes and in the majority of Euryarchaeota (but not in the Crenarchaeota), is involved in the hypermodification of the guanine nucleoside at position 37 of tRNA leading to formation of assorted wye bases.
  • This modification is essential for translational reading-frame maintenance.
  • The eukaryotic enzyme is involved in biosynthesis of the tricyclic base wybutosine, which is found only in tRNA(Phe).
Cross-references
BRENDA2.5.1.114
EC2PDB2.5.1.114
ExplorEnz2.5.1.114
PRIAM enzyme-specific profiles2.5.1.114
KEGG Ligand Database for Enzyme Nomenclature2.5.1.114
IUBMB Enzyme Nomenclature2.5.1.114
IntEnz2.5.1.114
MEDLINEFind literature relating to 2.5.1.114
MetaCyc2.5.1.114
Rhea expert-curated reactions2.5.1.114
UniProtKB/Swiss-Prot
Q8W4K1, TYW23_ARATHQ8H4D4, TYW23_ORYSJQ58D65, TYW2_BOVIN
Q0P466, TYW2_DANREQ53H54, TYW2_HUMANQ4R3U8, TYW2_MACFA
Q58952, TYW2_METJAQ8BG71, TYW2_MOUSEO58523, TYW2_PYRHO
Q4V8B8, TYW2_RATQ09832, TYW2_SCHPOQ04235, TYW2_YEAST

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.5.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.5.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-