| Official Name |
|---|
| NAD(P)(+)--protein-arginine ADP-ribosyltransferase.
|
| Alternative Name(s) |
|---|
| ADP-ribosyltransferase. |
| Mono(ADP-ribosyl)transferase. |
| NAD(+):L-arginine ADP-D-ribosyltransferase. |
| NAD(P)(+)--arginine ADP-ribosyltransferase. |
| Reaction catalysed |
|---|
- NAD(+) + protein-L-arginine <=> nicotinamide + N(omega)-(ADP-D-ribosyl)-protein-L-arginine
- NADP(+) + protein-L-arginine <=> nicotinamide + N(omega)-((2'-phospho-ADP)-D-ribosyl)-protein-L-arginine
|
| Comment(s) |
|---|
- Arginine residues in proteins act as acceptors.
- Free arginine, agmatine ((4-aminobutyl)guanidine), arginine methyl
ester and guanidine can also do so.
- Catalyzes the NAD(+)-dependent activation of EC 4.6.1.1.
- Some bacterial enterotoxins possess similar enzymatic activities (cf.
EC 2.4.2.36).
|
| Cross-references |
|---|
| PROSITE | PDOC00993 |
| BRENDA | 2.4.2.31 |
| PUMA2 | 2.4.2.31 |
| PRIAM enzyme-specific profiles | 2.4.2.31 |
| KEGG Ligand Database for Enzyme Nomenclature | 2.4.2.31 |
| IUBMB Enzyme Nomenclature | 2.4.2.31 |
| IntEnz | 2.4.2.31 |
| MEDLINE | Find literature relating to 2.4.2.31 |
| MetaCyc | 2.4.2.31 |
| UniProtKB/Swiss-Prot |
| P52961, NAR1_HUMAN; | Q60935, NAR1_MOUSE; | Q03515, NAR1_RABIT; |
| P17981, NAR2A_MOUSE; | P17982, NAR2A_RAT; | O35975, NAR2B_MOUSE; |
| P20974, NAR2B_RAT; | Q13508, NAR3_HUMAN; | Q8R2G4, NAR3_MOUSE; |
| Q93070, NAR4_HUMAN; | Q95NE0, NAR4_PANTR; | Q96L15, NAR5_HUMAN; |
| P70352, NAR5_MOUSE; | Q92080, NARE_CHICK; | P55806, NRT1_CHICK; |
| P55807, NRT2_CHICK; | Q8N6T7, SIRT6_HUMAN; | P59941, SIRT6_MOUSE; |
|
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