| Accepted Name |
|---|
| Globotriaosylceramide 3-beta-N-acetylgalactosaminyltransferase.
|
| Alternative Name(s) |
|---|
| Beta-3GalNAc-T1. |
| Galactosylgalactosylglucosylceramide beta-D-
acetylgalactosaminyltransferase. |
| Globoside synthase. |
| Globoside synthetase. |
| Uridine diphosphoacetylgalactosamine-galactosylgalactosylglucosylceramide
acetylgalactosaminyltransferase. |
| Reaction catalysed |
|---|
| UDP-N-acetyl-D-galactosamine + alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide <=> UDP + N-acetyl-beta-D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide |
| Cofactor(s) |
|---|
| Manganese.
|
| Comment(s) |
|---|
- Globoside is a neutral glycosphingolipid in human erythrocytes and
has blood-group-P-antigen activity.
- UDP-GalNAc is the only sugar donor that is used efficiently by the
enzyme: UDP-Gal and UDP-GlcNAc result in very low enzyme activity.
- Lactosylceramide, globoside and gangliosides GM3 and GD3 are not
substrates.
|
| Cross-references |
|---|
| BRENDA | 2.4.1.79 |
| EC2PDB | 2.4.1.79 |
| PRIAM enzyme-specific profiles | 2.4.1.79 |
| KEGG Ligand Database for Enzyme Nomenclature | 2.4.1.79 |
| IUBMB Enzyme Nomenclature | 2.4.1.79 |
| IntEnz | 2.4.1.79 |
| MEDLINE | Find literature relating to 2.4.1.79 |
| MetaCyc | 2.4.1.79 |
| UniProtKB/Swiss-Prot |
|
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