| Accepted Name |
|---|
| N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-
acetylgalactosaminyltransferase.
|
| Alternative Name(s) |
|---|
| Beta-1,4-N-acetylgalactosaminyltransferase. |
| Beta-4GalNAc-T3. |
| Beta-4GalNAc-T4. |
| Reaction catalysed |
|---|
| UDP-N-acetyl-D-galactosamine + N-acetyl-beta-D-glucosaminyl group <=> UDP + N-acetyl-beta-D-galactosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl group |
| Comment(s) |
|---|
- The enzyme from human can transfer N-acetyl-D-galactosamine (GalNAc)
to N-glycan and O-glycan substrates that have N-acetyl-D-glucosamine
(GlcNAc) but not D-glucuronic acid (GlcUA) at their non-reducing end.
- The N-acetyl-beta-D-glucosaminyl group is normally on a core
oligosaccharide although benzyl glycosides have been used in enzyme-
characterization experiments.
- Some glycohormones, e.g. lutropin and thyrotropin contain the
N-glycan structure containing the N-acetyl-beta-D-galactosaminyl-
(1->4)-N-acetyl-beta-D-glucosaminyl group.
|
| Cross-references |
|---|
| BRENDA | 2.4.1.244 |
| EC2PDB | 2.4.1.244 |
| PRIAM enzyme-specific profiles | 2.4.1.244 |
| KEGG Ligand Database for Enzyme Nomenclature | 2.4.1.244 |
| IUBMB Enzyme Nomenclature | 2.4.1.244 |
| IntEnz | 2.4.1.244 |
| MEDLINE | Find literature relating to 2.4.1.244 |
| MetaCyc | 2.4.1.244 |
| UniProtKB/Swiss-Prot |
|
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