| Accepted Name |
|---|
| N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase.
|
| Alternative Name(s) |
|---|
| Chondroitin glucuronyltransferase II. |
| Reaction catalysed |
|---|
| UDP-alpha-D-glucuronate + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-glucuronosyl-proteoglycan <=> UDP + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-glucuronosyl-proteoglycan |
| Comment(s) |
|---|
- Involved in the biosynthesis of chondroitin and dermatan sulfate.
- The human chondroitin synthetase is a bifunctional
glycosyltransferase, which also has the EC 2.4.1.175 activity
required for the synthesis of the chondroitin sulfate disaccharide
repeats.
- Similar chondroitin synthase 'copolymerases' can be found in
Pasteurella multocida and Escherichia coli.
- There is also another human protein with apparently only the 3-beta-
glucuronosyltransferase activity.
|
| Cross-references |
|---|
| BRENDA | 2.4.1.226 |
| EC2PDB | 2.4.1.226 |
| PRIAM enzyme-specific profiles | 2.4.1.226 |
| KEGG Ligand Database for Enzyme Nomenclature | 2.4.1.226 |
| IUBMB Enzyme Nomenclature | 2.4.1.226 |
| IntEnz | 2.4.1.226 |
| MEDLINE | Find literature relating to 2.4.1.226 |
| MetaCyc | 2.4.1.226 |
| UniProtKB/Swiss-Prot |
| Q9P2E5, CHGUT_HUMAN; | Q86X52, CHSS1_HUMAN; | Q6ZQ11, CHSS1_MOUSE; |
| P45895, CHSS2_CAEEL; | Q8IZ52, CHSS2_HUMAN; | Q6IQX7, CHSS2_MOUSE; |
| Q70JA7, CHSS3_HUMAN; | Q5DTK1, CHSS3_MOUSE; | Q8L0V4, CHS_ECOLX; |
| Q9CMP0, CHS_PASMU; | Q7BLV3, HAS_PASMU; |
|
ExPASy Home page