ID   2.4.1.212
DE   Hyaluronan synthase.
AN   HAS.
CA   (1) UDP-alpha-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1->3)-N-
CA   acetyl-beta-D-glucosaminyl-(1->4)-(nascent hyaluronan) = UDP + N-acetyl-
CA   beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-
CA   glucosaminyl-(1->4)-(nascent hyaluronan).
CA   (2) UDP-alpha-D-glucuronate + N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-
CA   glucuronosyl-(1->3)-(nascent hyaluronan) = UDP + beta-D-glucuronosyl-
CA   (1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-
CA   (1->3)-(nascent hyaluronan).
CF   Magnesium.
CC   -!- Adds GlcNAc to nascent hyaluronan when the non-reducing end is GlcA,
CC       but it adds GlcA when the non-reducing end is GlcNAc.
CC   -!- Highly specific for UDP-GlcNAc and UDP-GlcA; no copolymerization is
CC       observed if either is replaced by UDP-Glc, UDP-Gal, UDP-GalNAc or
CC       UDP-GalA.
DR   Q92839, HAS1_HUMAN ;  Q61647, HAS1_MOUSE ;  P13563, HAS1_XENLA ;
DR   O97711, HAS2_BOVIN ;  O57424, HAS2_CHICK ;  Q92819, HAS2_HUMAN ;
DR   P70312, HAS2_MOUSE ;  O35776, HAS2_RAT   ;  O57427, HAS2_XENLA ;
DR   O57425, HAS3_CHICK ;  O00219, HAS3_HUMAN ;  O08650, HAS3_MOUSE ;
DR   O57426, HAS3_XENLA ;  P0C0H1, HASA_STRP1 ;  Q8K5G6, HASA_STRP3 ;
DR   Q5X9A9, HASA_STRP6 ;  Q8NKX1, HASA_STRP8 ;  P0C0H0, HASA_STRPY ;
DR   Q7BLV3, HAS_PASMU  ;
//