| Accepted Name |
|---|
| Hyaluronan synthase.
|
| Alternative Name(s) |
|---|
| HAS. |
| Reaction catalysed |
|---|
- UDP-alpha-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-(nascent hyaluronan) <=> UDP + N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-(nascent hyaluronan)
- UDP-alpha-D-glucuronate + N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-(nascent hyaluronan) <=> UDP + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-(nascent hyaluronan)
|
| Cofactor(s) |
|---|
| Magnesium.
|
| Comment(s) |
|---|
- Adds GlcNAc to nascent hyaluronan when the non-reducing end is GlcA,
but it adds GlcA when the non-reducing end is GlcNAc.
- Highly specific for UDP-GlcNAc and UDP-GlcA; no copolymerization is
observed if either is replaced by UDP-Glc, UDP-Gal, UDP-GalNAc or
UDP-GalA.
|
| Cross-references |
|---|
| BRENDA | 2.4.1.212 |
| EC2PDB | 2.4.1.212 |
| PRIAM enzyme-specific profiles | 2.4.1.212 |
| KEGG Ligand Database for Enzyme Nomenclature | 2.4.1.212 |
| IUBMB Enzyme Nomenclature | 2.4.1.212 |
| IntEnz | 2.4.1.212 |
| MEDLINE | Find literature relating to 2.4.1.212 |
| MetaCyc | 2.4.1.212 |
| UniProtKB/Swiss-Prot |
| Q92839, HAS1_HUMAN; | Q61647, HAS1_MOUSE; | P13563, HAS1_XENLA; |
| O97711, HAS2_BOVIN; | O57424, HAS2_CHICK; | Q92819, HAS2_HUMAN; |
| P70312, HAS2_MOUSE; | O35776, HAS2_RAT; | O57427, HAS2_XENLA; |
| O57425, HAS3_CHICK; | O00219, HAS3_HUMAN; | O08650, HAS3_MOUSE; |
| O57426, HAS3_XENLA; | P0C0H1, HASA_STRP1; | Q8K5G6, HASA_STRP3; |
| Q5X9A9, HASA_STRP6; | Q8NKX1, HASA_STRP8; | P0C0H0, HASA_STRPY; |
| Q7BLV3, HAS_PASMU; |
|
ExPASy Home page