| Accepted Name |
|---|
| Glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-
acetylgalactosaminyltransferase.
|
| Alternative Name(s) |
|---|
| Chondroitin synthase. |
| Glucuronyl-N-acetylgalactosaminylproteoglycan beta-1,4-N-
acetylgalactosaminyltransferase. |
| N-acetylgalactosaminyltransferase II. |
| UDP-N-acetyl-D-galactosamine:D-glucuronyl-N-acetyl-1,3-beta-D-
galactosaminylproteoglycan beta-1,4-N-acetylgalactosaminyltransferase. |
| Uridine diphosphoacetylgalactosamine-chondroitin
acetylgalactosaminyltransferase II. |
| Reaction catalysed |
|---|
| UDP-N-acetyl-D-galactosamine + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-proteoglycan <=> UDP + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-proteoglycan |
| Comment(s) |
|---|
- Involved in the biosynthesis of chondroitin sulfate.
- The human form of this enzyme is a bifunctional glycosyltransferase,
which also has the EC 2.4.1.226 activity required for the synthesis
of the chondroitin sulfate disaccharide repeats.
- Similar chondroitin synthase 'copolymerases' can be found in
Pasteurella multocida and Escherichia coli.
|
| Cross-references |
|---|
| BRENDA | 2.4.1.175 |
| EC2PDB | 2.4.1.175 |
| PRIAM enzyme-specific profiles | 2.4.1.175 |
| KEGG Ligand Database for Enzyme Nomenclature | 2.4.1.175 |
| IUBMB Enzyme Nomenclature | 2.4.1.175 |
| IntEnz | 2.4.1.175 |
| MEDLINE | Find literature relating to 2.4.1.175 |
| MetaCyc | 2.4.1.175 |
| UniProtKB/Swiss-Prot |
|
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