ExPASy Proteomics Server

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NiceZyme View of ENZYME: EC 2.3.1.94

Accepted Name

6-deoxyerythronolide-B synthase.

Alternative Name(s)

6-deoxyerythronolide B synthase.

DEBS.

Deoxyerythronolide B synthase.

Erythronolide synthase.

Erythronolide-condensing enzyme.

Reaction catalysed

Propanoyl-CoA + 6 (2S)-methylmalonyl-CoA + 6 NADPH <=> 6-deoxyerythronolide B + 7 CoA + 6 CO(2) + H(2)O + 6 NADP(+)

Comment(s)

The product, 6-deoxyerythronolide B, contains a 14-membered lactone ring and is an intermediate in the biosynthesis of erythromycin antibiotics.
Biosynthesis of 6-deoxyerythronolide B requires 28 active sites that are precisely arranged along three large polypeptides, denoted DEBS1, -2 and -3.
The polyketide product is synthesized by the processive action of a loading didomain, six extension modules and a terminal thioesterase domain.
Each extension module contains a minimum of a ketosynthase (KS), an acyltransferase (AT) and an acyl-carrier protein (ACP).
The KS domain both accepts the growing polyketide chain from the previous module and catalyzes the subsequent decarboxylative condensation between this substrate and an ACP-bound methylmalonyl extender unit, introduce by the AT domain.
This combined effort gives rise to a new polyketide intermediate that has been extended by two carbon atoms.

Cross-references

BRENDA

EC2PDB

PRIAM enzyme-specific profiles

KEGG Ligand Database for Enzyme Nomenclature

IUBMB Enzyme Nomenclature

IntEnz