| Official Name |
|---|
| 5-hydroxyfuranocoumarin 5-O-methyltransferase.
|
| Alternative Name(s) |
|---|
| Bergaptol 5-O-methyltransferase. |
| Bergaptol methyltransferase. |
| Bergaptol O-methyltransferase. |
| BMT. |
| Furanocoumarin 5-methyltransferase. |
| Furanocoumarin 5-O-methyltransferase. |
| Reaction catalysed |
|---|
- S-adenosyl-L-methionine + a 5-hydroxyfurocoumarin <=> S-adenosyl-L-homocysteine + a 5-methoxyfurocoumarin
- S-adenosyl-L-methionine + bergaptol <=> S-adenosyl-L-homocysteine + bergapten
|
| Comment(s) |
|---|
- Converts bergaptol into bergapten, which has therapeutic potential in
the treatment of psoriasis as it has photosensitizing and
antiproliferative activities.
- Methylates the 5-hydroxy group of some hydroxy- and methylcoumarins,
such as 5-hydroxyxanthotoxin, but has little activity on non-coumarin
phenols; caffeate, 5-hydroxyferulate and daphnetin are not
substrates.
- Cu(2+), Zn(2+) and Co(2+) cause enzyme inhibition.
- See also EC 2.1.1.70.
|
| Cross-references |
|---|
| BRENDA | 2.1.1.69 |
| PUMA2 | 2.1.1.69 |
| PRIAM enzyme-specific profiles | 2.1.1.69 |
| KEGG Ligand Database for Enzyme Nomenclature | 2.1.1.69 |
| IUBMB Enzyme Nomenclature | 2.1.1.69 |
| IntEnz | 2.1.1.69 |
| MEDLINE | Find literature relating to 2.1.1.69 |
| MetaCyc | 2.1.1.69 |
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