| Official Name |
|---|
| Sterol 24-C-methyltransferase.
|
| Alternative Name(s) |
|---|
| 24-sterol C-methyltransferase. |
| Delta(24)-methyltransferase. |
| Delta(24)-sterol methyltransferase. |
| Phytosterol methyltransferase. |
| S-adenosyl-4-methionine:sterol Delta(24)-methyltransferase. |
| S-adenosyl-L-methionine:Delta(24(23))-sterol methyltransferase. |
| SMT1. |
| Zymosterol-24-methyltransferase. |
| Reaction catalysed |
|---|
| S-adenosyl-L-methionine + 5-alpha-cholesta-8,24-dien-3-beta-ol <=> S-adenosyl-L-homocysteine + 24-methylene-5-alpha-cholest-8-en-3-beta-ol |
| Cofactor(s) |
|---|
| Glutathione.
|
| Comment(s) |
|---|
- Acts on a range of sterols with a 24(25)-double bond in the side
chain.
- While zymosterol is the preferred substrate it also acts on
desmosterol, 5-alpha-cholesta-7,24-dien-3-beta-ol, 5-alpha-cholesta-
5,7,24-trien-3-beta-ol, 4-alpha-methylzymosterol and others.
- S-adenosyl-L-methionine attacks the Si face of the 24(25) double bond
and the C-24 hydrogen is transferred to C-25 on the Re face of the
double bond.
|
| Cross-references |
|---|
| BRENDA | 2.1.1.41 |
| PUMA2 | 2.1.1.41 |
| PRIAM enzyme-specific profiles | 2.1.1.41 |
| KEGG Ligand Database for Enzyme Nomenclature | 2.1.1.41 |
| IUBMB Enzyme Nomenclature | 2.1.1.41 |
| IntEnz | 2.1.1.41 |
| MEDLINE | Find literature relating to 2.1.1.41 |
| MetaCyc | 2.1.1.41 |
| UniProtKB/Swiss-Prot |
| Q759S7, ERG6_ASHGO; | O74198, ERG6_CANAL; | Q6FRZ7, ERG6_CANGA; |
| Q875K1, ERG6_CLALS; | Q6BRB7, ERG6_DEBHA; | Q6CYB3, ERG6_KLULA; |
| Q5EN22, ERG6_MAGGR; | Q9P3R1, ERG6_NEUCR; | Q96WX4, ERG6_PNECA; |
| O14321, ERG6_SCHPO; | Q6C2D9, ERG6_YARLI; | P25087, ERG6_YEAST; |
| Q9LM02, SMT1_ARATH; | Q54I98, SMT1_DICDI; | Q6ZIX2, SMT1_ORYSJ; |
|
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