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ENZYME

ENZYME entry: EC 2.1.1.148

Accepted Name
thymidylate synthase (FAD)
Alternative Name(s)
FDTS
flavin dependent thymidylate synthase
Reaction catalysed
(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP + H(+) + NADPH <=> (6S)-5,6,7,8-tetrahydrofolate + dTMP + NADP(+)
Comment(s)
  • Contains FAD.
  • All thymidylate synthases catalyze a reductive methylation involving the transfer of the methylene group of 5,10-methylenetetrahydrofolate to the C5-position of dUMP and a two electron reduction of the methylene group to a methyl group.
  • Unlike the classical thymidylate synthase, ThyA (EC 2.1.1.45), which uses folate as both a 1-carbon donor and a source of reducing equivalents, this enzyme uses a flavin cofactor as a source of reducing equivalents, which are derived from NADPH.
Cross-references
BRENDA2.1.1.148
EC2PDB2.1.1.148
ExplorEnz2.1.1.148
PRIAM enzyme-specific profiles2.1.1.148
KEGG Ligand Database for Enzyme Nomenclature2.1.1.148
IUBMB Enzyme Nomenclature2.1.1.148
IntEnz2.1.1.148
MEDLINEFind literature relating to 2.1.1.148
MetaCyc2.1.1.148
Rhea expert-curated reactions2.1.1.148
UniProtKB/Swiss-Prot
P15808, THY1_DICDIQ9YA75, THYX_AERPEQ5PBM3, THYX_ANAMM
O66883, THYX_AQUAEO50965, THYX_BORBUO64238, THYX_BPMD2
Q05259, THYX_BPML5Q9ZX92, THYX_BPPHCQ9PJ85, THYX_CAMJE
Q5HXD2, THYX_CAMJRQ8XHQ7, THYX_CLOPEQ890M6, THYX_CLOTE
C3PH05, THYX_CORA7Q6NGP3, THYX_CORDIQ8RQM9, THYX_COREF
P40111, THYX_CORGLQ729U4, THYX_DESVHQ5FG35, THYX_EHRRG
Q5HAK2, THYX_EHRRWQ748A9, THYX_GEOSLQ5FR18, THYX_GLUOX
Q5V325, THYX_HALMAQ9HQ52, THYX_HALSAQ9ZJ93, THYX_HELPJ
O26061, THYX_HELPYC5CHB8, THYX_KOSOTA0QIT4, THYX_MYCA1
B1MD42, THYX_MYCA9P66931, THYX_MYCBOA1KM95, THYX_MYCBP
C1AFL6, THYX_MYCBTA4TCJ4, THYX_MYCGIB8ZRR4, THYX_MYCLB
Q9CBW3, THYX_MYCLEB2HKZ0, THYX_MYCMMQ73VZ6, THYX_MYCPA
A0QVT0, THYX_MYCS2A3PYB1, THYX_MYCSJA1UEV1, THYX_MYCSK
Q1BA61, THYX_MYCSSA5U6A7, THYX_MYCTAP9WG56, THYX_MYCTO
P9WG57, THYX_MYCTUA1T7Q0, THYX_MYCVPO41156, THYX_PBCV1
A8F7Q7, THYX_PSELTQ9UZ51, THYX_PYRABQ8ZWD6, THYX_PYRAE
Q8U3C9, THYX_PYRFUO58498, THYX_PYRHOQ1RJV8, THYX_RICBR
Q92IL5, THYX_RICCNQ4UM78, THYX_RICFEQ9ZDM6, THYX_RICPR
Q68X70, THYX_RICTYQ5LTY7, THYX_RUEPOQ980H6, THYX_SACS2
Q82K86, THYX_STRAWO86840, THYX_STRCOQ4J6F2, THYX_SULAC
Q96YF6, THYX_SULTOP73053, THYX_SYNY3B7IF44, THYX_THEAB
Q5JI17, THYX_THEKOA6LP90, THYX_THEM4Q9WYT0, THYX_THEMA
B9KBK3, THYX_THENNB6YTN5, THYX_THEONA5IJX2, THYX_THEP1
B1L944, THYX_THESQQ72JN9, THYX_THET2Q5SJB8, THYX_THET8
Q73QY2, THYX_TREDEO83971, THYX_TREPAQ83HF9, THYX_TROW8
Q83MS7, THYX_TROWTQ73FX5, THYX_WOLPMQ7MQK8, THYX_WOLSU

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