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NiceZyme View of ENZYME: EC 2.1.1.14

Official Name
5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase.
Alternative Name(s)
Cobalamin-independent methionine synthase.
Homocysteine methylase.
Methionine synthase (cobalamin-independent).
Methyltetrahydropteroylpolyglutamate:homocysteine methyltransferase.
Tetrahydropteroylglutamate-homocysteine transmethylase.
Reaction catalysed
5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine <=> tetrahydropteroyltri-L-glutamate + L-methionine
Cofactor(s)
Zinc.
Comment(s)
  • Requires phosphate.
  • The enzyme from Escherichia coli also requires a reducing system.
  • Unlike EC 2.1.1.13 this enzyme does not contain cobalamin.
Cross-references
Biochemical Pathways; map number(s)H3
BRENDA2.1.1.14
PUMA22.1.1.14
PRIAM enzyme-specific profiles2.1.1.14
KEGG Ligand Database for Enzyme Nomenclature2.1.1.14
IUBMB Enzyme Nomenclature2.1.1.14
IntEnz2.1.1.14
MEDLINEFind literature relating to 2.1.1.14
MetaCyc2.1.1.14

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-

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