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ENZYME

ENZYME entry: EC 1.8.98.1

Accepted Name
dihydromethanophenazine:CoB--CoM heterodisulfide reductase
Alternative Name(s)
CoB--CoM heterodisulfide reductase
heterodisulfide reductase
Reaction catalysed
coenzyme B + coenzyme M + methanophenazine <=> coenzyme M-coenzyme B heterodisulfide + dihydromethanophenazine
Comment(s)
  • This enzyme, found in methanogenic archaea that belong to the Methanosarcinales order, regenerates CoM and CoB after the action of EC 2.8.4.1.
  • It is a membrane-bound enzyme that contains (per heterodimeric unit) two distinct b-type hemes and two [4Fe-4S] clusters. cf. EC 1.8.7.3, EC 1.8.98.5, EC 1.8.98.6 and EC 1.8.98.4.
Cross-references
BRENDA1.8.98.1
EC2PDB1.8.98.1
ExplorEnz1.8.98.1
PRIAM enzyme-specific profiles1.8.98.1
KEGG Ligand Database for Enzyme Nomenclature1.8.98.1
IUBMB Enzyme Nomenclature1.8.98.1
IntEnz1.8.98.1
MEDLINEFind literature relating to 1.8.98.1
MetaCyc1.8.98.1
Rhea expert-curated reactions1.8.98.1
UniProtKB/Swiss-Prot
Q8TSV7, HDRD_METACP96797, HDRD_METBFQ8PVW3, HDRD_METMA
A0A0E3NEE1, HDRD_METTTQ8TSV8, HDRE_METACP96796, HDRE_METBF
Q8PVW4, HDRE_METMAA0A0E3NFS5, HDRE_METTT

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