| Accepted Name |
|---|
| NADPH:quinone reductase.
|
| Alternative Name(s) |
|---|
| Quinone oxidoreductase. |
| Zeta-crystallin. |
| Reaction catalysed |
|---|
| NADPH + 2 quinone <=> NADP(+) + 2 semiquinone |
| Cofactor(s) |
|---|
| Zinc.
|
| Comment(s) |
|---|
- Specific for NADPH.
- Catalyzes the one-electron reduction of certain quinones, with the
orthoquinones 1,2-naphthoquinone and 9,10-phenanthrenequinone being
the best substrates.
- Dicoumarol (cf. EC 1.6.5.2) and nitrofurantoin are competitive
inhibitors with respect to the quinone substrate.
- The semiquinone free-radical product may be non-enzymically reduced
to the hydroquinone or oxidized back to quinone in the presence of
O(2).
- Abundant in the lens of the eye of some mammalian species.
|
| Cross-references |
|---|
| PROSITE | PDOC00058 |
| BRENDA | 1.6.5.5 |
| EC2PDB | 1.6.5.5 |
| PRIAM enzyme-specific profiles | 1.6.5.5 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.6.5.5 |
| IUBMB Enzyme Nomenclature | 1.6.5.5 |
| IntEnz | 1.6.5.5 |
| MEDLINE | Find literature relating to 1.6.5.5 |
| MetaCyc | 1.6.5.5 |
| UniProtKB/Swiss-Prot |
| P11415, QOR_CAVPO; | P28304, QOR_ECOLI; | Q08257, QOR_HUMAN; |
| Q28452, QOR_LAMGU; | P42865, QOR_LEIAM; | P47199, QOR_MOUSE; |
| Q0MVN8, QOR_PIG; | Q5R4S7, QOR_PONAB; | P43903, QOR_PSEAE; |
| Q6AYT0, QOR_RAT; | P40783, QOR_SALTY; | O74489, QOR_SCHPO; |
| P38230, QOR_YEAST; |
|
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